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CryoEM structure of Gi-coupled MRGPRX1 with peptide agonist CNF-Tx2
Resolution: 2.84 Å
EM Method: Single-particle
Fitted PDBs: 8jgb
Q-score: 0.551
Guo L, Zhang Y, Fang G, Tie L, Zhuang Y, Xue C, Liu Q, Zhang M, Zhu K, You C, Xu P, Yuan Q, Zhang C, Liu L, Rong N, Peng S, Liu Y, Wang C, Luo X, Lv Z, Kang D, Yu X, Zhang C, Jiang Y, Dong X, Zhou J, Liu Z, Yang F, Eric Xu H, Sun JP
Nat Commun (2023) 14 pp. 5004-5004 [ DOI: doi:10.1038/s41467-023-40705-z Pubmed: 37591889 ]
- Scfv16 (30 kDa, Protein from Homo sapiens)
- Cryo-em structure of the bam8-22-bound mrgprx1-gq complex (Complex from Homo sapiens)
- Guanine nucleotide-binding protein g(i) subunit alpha-1 (40 kDa, Protein from Homo sapiens)
- Conorfamide-tx2 (2 kDa, Protein from Conus textile)
- Mas-related g-protein coupled receptor member x1 (35 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (6 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (39 kDa, Protein from Homo sapiens)
CryoEM structure of Gq-coupled MRGPRX1 with peptide agonist BAM8-22
Resolution: 2.7 Å
EM Method: Single-particle
Fitted PDBs: 8jgf
Q-score: 0.486
Guo L, Zhang Y, Fang G, Tie L, Zhuang Y, Xue C, Liu Q, Zhang M, Zhu K, You C, Xu P, Yuan Q, Zhang C, Liu L, Rong N, Peng S, Liu Y, Wang C, Luo X, Lv Z, Kang D, Yu X, Zhang C, Jiang Y, Dong X, Zhou J, Liu Z, Yang F, Eric Xu H, Sun JP
Nat Commun (2023) 14 pp. 5004-5004 [ DOI: doi:10.1038/s41467-023-40705-z Pubmed: 37591889 ]
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (38 kDa, Protein from Homo sapiens)
- Cryo-em structure of the bam8-22-bound mrgprx1-gq complex (Complex from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (6 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein gq (41 kDa, Protein from Homo sapiens)
- Bam8-22 (1 kDa, Protein from Homo sapiens)
- Mas-related g-protein coupled receptor member x1 (35 kDa, Protein from Homo sapiens)
- Single-chain fragment variable 16 (30 kDa, Protein from Homo sapiens)
CryoEM structure of Gi-coupled MRGPRX1 with peptide agonist BAM8-22
Resolution: 3.0 Å
EM Method: Single-particle
Fitted PDBs: 8jgg
Q-score: 0.54
Guo L, Zhang Y, Fang G, Tie L, Zhuang Y, Xue C, Liu Q, Zhang M, Zhu K, You C, Xu P, Yuan Q, Zhang C, Liu L, Rong N, Peng S, Liu Y, Wang C, Luo X, Lv Z, Kang D, Yu X, Zhang C, Jiang Y, Dong X, Zhou J, Liu Z, Yang F, Eric Xu H, Sun JP
Nat Commun (2023) 14 pp. 5004-5004 [ DOI: doi:10.1038/s41467-023-40705-z Pubmed: 37591889 ]
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (38 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i) subunit alpha-1 (40 kDa, Protein from Homo sapiens)
- Cryoem structure of gi-coupled mrgprx1 with peptide agonist bam8-22 (Complex from Homo sapiens)
- Mas-related g-protein coupled receptor member x1 (36 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (6 kDa, Protein from Homo sapiens)
- Bam8-22 (1 kDa, Protein from Homo sapiens)
- Single-chain fragment variable 16 (30 kDa, Protein from Homo sapiens)
Resolution: 3.0 Å
EM Method: Single-particle
Fitted PDBs: 7w3z
Q-score: 0.51
Peng S, Zhan Y, Zhang D, Ren L, Chen A, Chen ZF, Zhang H
PNAS (2023) 120 pp. e2216230120-e2216230120 [ Pubmed: 36724251 DOI: doi:10.1073/pnas.2216230120 ]
- Maltodextrin-binding protein,gastrin-releasing peptide receptor (99 kDa, Protein from Homo sapiens)
- Human gastrin releasing peptide receptor in complex with the agonist gastrin releasing peptide and gq heterotrimers and scfv16 (Complex from Homo sapiens)
- Gastrin releasing peptide prgnhwavghlm(nh2) (1 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (9 kDa, Protein from Homo sapiens)
- Scfv16 (32 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (41 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(q) subunit alpha (41 kDa, Protein from Homo sapiens)
Resolution: 3.0 Å
EM Method: Single-particle
Fitted PDBs: 7w40
Q-score: 0.437
Peng S, Zhan Y, Zhang D, Ren L, Chen A, Chen ZF, Zhang H
PNAS (2023) 120 pp. e2216230120-e2216230120 [ Pubmed: 36724251 DOI: doi:10.1073/pnas.2216230120 ]
- Maltodextrin-binding protein,gastrin-releasing peptide receptor (99 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (9 kDa, Protein from Homo sapiens)
- Scfv16 (32 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (41 kDa, Protein from Homo sapiens)
- Bombesin (1 kDa, Protein from synthetic construct)
- Guanine nucleotide-binding protein g(q) subunit alpha (41 kDa, Protein from Homo sapiens)
- Peptide receptor in complex with the agonist bombesin (6-14) [d-phe6, beta-ala11, phe13, nle14] and gq heterotrimers and scfv16 (Complex from Homo sapiens)
Yeast Dmc1 presynaptic complex
Resolution: 3.21 Å
EM Method: Helical reconstruction
Fitted PDBs: 7ej6
Q-score: 0.524
Xu J, Zhao L, Peng S, Chu H, Liang R, Tian M, Connell PP, Li G, Chen C, Wang HW
Nucleic Acids Res (2021) 49 pp. 13135-13149 [ DOI: doi:10.1093/nar/gkab1141 Pubmed: 34871438 ]
- Magnesium ion (24 Da, Ligand)
- Dna (5'-d(p*tp*tp*tp*tp*tp*tp*tp*tp*t)-3') (2 kDa, DNA from Saccharomyces cerevisiae)
- Yeast dmc1 presynaptic complex (Complex from Saccharomyces cerevisiae)
- Hlj1_g0016300.mrna.1.cds.1 (36 kDa, Protein from Saccharomyces cerevisiae)
- Adenosine-5'-triphosphate (507 Da, Ligand)
Yeast Dmc1 post-synaptic complex
Resolution: 3.41 Å
EM Method: Helical reconstruction
Fitted PDBs: 7ej7
Q-score: 0.505
Xu J, Zhao L, Peng S, Chu H, Liang R, Tian M, Connell PP, Li G, Chen C, Wang HW
Nucleic Acids Res (2021) 49 pp. 13135-13149 [ DOI: doi:10.1093/nar/gkab1141 Pubmed: 34871438 ]
- Magnesium ion (24 Da, Ligand)
- Yeast dmc1 post-synaptic complex (Complex from Saccharomyces cerevisiae)
- Dna (5'-d(p*tp*tp*tp*tp*tp*tp*tp*tp*t)-3') (2 kDa, DNA from Saccharomyces cerevisiae)
- Dna (5'-d(p*ap*ap*ap*ap*ap*ap*ap*ap*a)-3') (2 kDa, DNA from Saccharomyces cerevisiae)
- Hlj1_g0016300.mrna.1.cds.1 (36 kDa, Protein from Saccharomyces cerevisiae)
- Adenosine-5'-triphosphate (507 Da, Ligand)
human RAD51 presynaptic complex
Resolution: 2.97 Å
EM Method: Helical reconstruction
Fitted PDBs: 7ejc
Q-score: 0.554
Xu J, Zhao L, Peng S, Chu H, Liang R, Tian M, Connell PP, Li G, Chen C, Wang HW
Nucleic Acids Res (2021) 49 pp. 13135-13149 [ DOI: doi:10.1093/nar/gkab1141 Pubmed: 34871438 ]
- Magnesium ion (24 Da, Ligand)
- Dna (5'-d(p*tp*tp*tp*tp*tp*tp*tp*tp*t)-3') (2 kDa, DNA from Homo sapiens)
- Human rad51 presynaptic complex (Complex)
- Dna repair protein rad51 homolog 1 (37 kDa, Protein from Homo sapiens)
- 4-bromanyl-n-(4-bromophenyl)-3-[(phenylmethyl)sulfamoyl]benzamide (524 Da, Ligand)
- Phosphoaminophosphonic acid-adenylate ester (506 Da, Ligand)
- Dna (Complex from Homo sapiens)
- Human rad51 (Complex from Homo sapiens)
hRAD51 mutation 273-DG-274 postsynaptic complex with dsDNA after strand exchange process.
human RAD51 post-synaptic complex
Resolution: 3.98 Å
EM Method: Helical reconstruction
Fitted PDBs: 7eje
Q-score: 0.382
Xu J, Zhao L, Peng S, Chu H, Liang R, Tian M, Connell PP, Li G, Chen C, Wang HW
Nucleic Acids Res (2021) 49 pp. 13135-13149 [ DOI: doi:10.1093/nar/gkab1141 Pubmed: 34871438 ]
- Dna (5'-d(p*ap*ap*ap*ap*ap*ap*ap*ap*a)-3') (2 kDa, DNA from Homo sapiens)
- Magnesium ion (24 Da, Ligand)
- Dna (5'-d(p*tp*tp*tp*tp*tp*tp*tp*tp*t)-3') (2 kDa, DNA from Homo sapiens)
- Dna repair protein rad51 homolog 1 (37 kDa, Protein from Homo sapiens)
- Phosphoaminophosphonic acid-adenylate ester (506 Da, Ligand)
- Human rad51 (Complex)
- Human rad51 post-synaptic complex (Complex from Homo sapiens)
- Dna (Complex)