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Phosphoinositide phosphate 3 kinase gamma
Resolution: 3.03 Å
EM Method: Single-particle
Fitted PDBs: 8so9
Q-score: 0.514
Chen CL, Syahirah R, Ravala SK, Yen YC, Klose T, Deng Q, Tesmer JJG
Nat Struct Mol Biol (2024) [ DOI: doi:10.1038/s41594-024-01265-y Pubmed: 38565696 ]
Phosphoinositide phosphate 3 kinase gamma bound with ATP
Resolution: 3.32 Å
EM Method: Single-particle
Fitted PDBs: 8soa
Q-score: 0.425
Chen CL, Syahirah R, Ravala SK, Yen YC, Klose T, Deng Q, Tesmer JJG
Nat Struct Mol Biol (2024) [ DOI: doi:10.1038/s41594-024-01265-y Pubmed: 38565696 ]
- Pi3k-gamma-atp (210 MDa, Complex from Sus scrofa)
- Adenosine-5'-triphosphate (507 Da, Ligand)
- Phosphatidylinositol-4,5-bisphosphate 3-kinase (127 kDa, Protein from Sus scrofa)
- Phosphoinositide 3-kinase regulatory subunit 5 (98 kDa, Protein from Sus scrofa)
Phosphoinositide phosphate 3 kinase gamma bound with ADP
Resolution: 3.9 Å
EM Method: Single-particle
Fitted PDBs: 8sob
Q-score: 0.37
Chen CL, Syahirah R, Ravala SK, Yen YC, Klose T, Deng Q, Tesmer JJG
Nat Struct Mol Biol (2024) [ DOI: doi:10.1038/s41594-024-01265-y Pubmed: 38565696 ]
- Phosphoinositide 3-kinase regulatory subunit 5 (98 kDa, Protein from Sus scrofa)
- Adenosine-5'-diphosphate (427 Da, Ligand)
- Phosphatidylinositol-4,5-bisphosphate 3-kinase (127 kDa, Protein from Sus scrofa)
- Pi3k-gamma-adpbef3 (210 MDa, Complex from Sus scrofa)
Phosphoinositide phosphate 3 kinase gamma bound with ADP and Gbetagamma
Resolution: 3.5 Å
EM Method: Single-particle
Fitted PDBs: 8soc
Q-score: 0.337
Chen CL, Syahirah R, Ravala SK, Yen YC, Klose T, Deng Q, Tesmer JJG
Nat Struct Mol Biol (2024) [ DOI: doi:10.1038/s41594-024-01265-y Pubmed: 38565696 ]
- Adenosine-5'-diphosphate (427 Da, Ligand)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (37 kDa, Protein from Bos taurus)
- Pi3k-gamma-adp bound with gbetagamma (210 MDa, Complex from Sus scrofa)
- Phosphatidylinositol-4,5-bisphosphate 3-kinase (127 kDa, Protein from Sus scrofa)
- Phosphoinositide 3-kinase regulatory subunit 5 (98 kDa, Protein from Sus scrofa)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (8 kDa, Protein from Bos taurus)
Phosphoinositide phosphate 3 kinase gamma bound with ADP and two Gbetagamma subunits in State 1
Resolution: 3.4 Å
EM Method: Single-particle
Fitted PDBs: 8sod
Q-score: 0.268
Chen CL, Syahirah R, Ravala SK, Yen YC, Klose T, Deng Q, Tesmer JJG
Nat Struct Mol Biol (2024) [ DOI: doi:10.1038/s41594-024-01265-y Pubmed: 38565696 ]
- Adenosine-5'-diphosphate (427 Da, Ligand)
- Pi3k-gamma-adp bound with two gbetagamma subunits in state 1 (210 MDa, Complex from Sus scrofa)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (37 kDa, Protein from Bos taurus)
- Phosphatidylinositol-4,5-bisphosphate 3-kinase (127 kDa, Protein from Sus scrofa)
- Phosphoinositide 3-kinase regulatory subunit 5 (98 kDa, Protein from Sus scrofa)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (8 kDa, Protein from Bos taurus)
Phosphoinositide phosphate 3 kinase gamma bound with ADP and two Gbetagamma subunits in State 2
Resolution: 3.6 Å
EM Method: Single-particle
Fitted PDBs: 8soe
Q-score: 0.254
Chen CL, Syahirah R, Ravala SK, Yen YC, Klose T, Deng Q, Tesmer JJG
Nat Struct Mol Biol (2024) [ DOI: doi:10.1038/s41594-024-01265-y Pubmed: 38565696 ]
- Pi3k-gamma-adp bound with two gbetagamma subunits in state 2 (210 MDa, Complex from Sus scrofa)
- Adenosine-5'-diphosphate (427 Da, Ligand)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (37 kDa, Protein from Bos taurus)
- Phosphatidylinositol-4,5-bisphosphate 3-kinase (127 kDa, Protein from Sus scrofa)
- Phosphoinositide 3-kinase regulatory subunit 5 (98 kDa, Protein from Sus scrofa)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (8 kDa, Protein from Bos taurus)
The state 2 complex structure of Omicron spike with Bn03 (2-up RBD, 4 nanobodies)
Resolution: 2.93 Å
EM Method: Single-particle
Fitted PDBs: 7whi
Q-score: 0.377
Li C, Zhan W, Yang Z, Tu C, Hu G, Zhang X, Song W, Du S, Zhu Y, Huang K, Kong Y, Zhang M, Mao Q, Gu X, Zhang Y, Xie Y, Deng Q, Song Y, Chen Z, Lu L, Jiang S, Wu Y, Sun L, Ying T
Cell (2022) 185 pp. 1389-1401.e18 [ Pubmed: 35344711 DOI: doi:10.1016/j.cell.2022.03.009 ]
- Bn03_nano1 (14 kDa, Protein from Homo sapiens)
- Omicron spike (Complex from Severe acute respiratory syndrome coronavirus 2)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Spike glycoprotein (142 kDa, Protein from Severe acute respiratory syndrome coronavirus 2)
- Bn03 (Complex from Homo sapiens)
- The state 2 complex structure of omicron spike with bn03 (2-up rbd, 4 nanobodies) (Complex)
- Bn03_nano2 (13 kDa, Protein from Homo sapiens)
The state 1 complex structure of Omicron spike with Bn03 (1-up RBD, 3 nanobodies)
Resolution: 3.27 Å
EM Method: Single-particle
Fitted PDBs: 7whj
Q-score: 0.38
Li C, Zhan W, Yang Z, Tu C, Hu G, Zhang X, Song W, Du S, Zhu Y, Huang K, Kong Y, Zhang M, Mao Q, Gu X, Zhang Y, Xie Y, Deng Q, Song Y, Chen Z, Lu L, Jiang S, Wu Y, Sun L, Ying T
Cell (2022) 185 pp. 1389-1401.e18 [ Pubmed: 35344711 DOI: doi:10.1016/j.cell.2022.03.009 ]
- Bn03_nano1 (14 kDa, Protein from Homo sapiens)
- Omicron spike (Complex from Severe acute respiratory syndrome coronavirus 2)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- The state 1 complex structure of omicron spike with bn03 (1-up rbd, 3 nanobodies) (Complex)
- Spike glycoprotein (142 kDa, Protein from Severe acute respiratory syndrome coronavirus 2)
- Bn03 (Complex from Homo sapiens)
- Bn03_nano2 (13 kDa, Protein from Homo sapiens)
The state 3 complex structure of Omicron spike with Bn03 (2-up RBD, 5 nanobodies)
Resolution: 3.01 Å
EM Method: Single-particle
Fitted PDBs: 7whk
Q-score: 0.37
Li C, Zhan W, Yang Z, Tu C, Hu G, Zhang X, Song W, Du S, Zhu Y, Huang K, Kong Y, Zhang M, Mao Q, Gu X, Zhang Y, Xie Y, Deng Q, Song Y, Chen Z, Lu L, Jiang S, Wu Y, Sun L, Ying T
Cell (2022) 185 pp. 1389-1401.e18 [ Pubmed: 35344711 DOI: doi:10.1016/j.cell.2022.03.009 ]
- Bn03_nano1 (14 kDa, Protein from Homo sapiens)
- Omicron spike (Complex from Severe acute respiratory syndrome coronavirus 2)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Omicron spike with bn03 (Complex)
- Spike glycoprotein (142 kDa, Protein from Severe acute respiratory syndrome coronavirus 2)
- Bn03 (Complex from Homo sapiens)
- Bn03_nano2 (13 kDa, Protein from Homo sapiens)