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Cryo-EM structure of tetrameric human SAMHD1 with dApNHpp
Resolution: 2.65 Å
EM Method: Single-particle
Fitted PDBs: 8qxj
Q-score: 0.574
Acton OJ, Sheppard D, Kunzelmann S, Caswell SJ, Nans A, Burgess AJO, Kelly G, Morris ER, Rosenthal PB, Taylor IA
Nat Commun (2024) 15 pp. 3775-3775 [ DOI: doi:10.1038/s41467-024-48237-w Pubmed: 38710701 ]
- Fe (iii) ion (55 Da, Ligand)
- Homotetramer of samhd1 (Complex from Homo sapiens)
- 2'-deoxy-5'-o-[(r)-hydroxy{[(r)-hydroxy(phosphonooxy)phosphoryl]amino}phosphoryl]adenosine (490 Da, Ligand)
- Magnesium ion (24 Da, Ligand)
- Guanosine-5'-triphosphate (523 Da, Ligand)
- Deoxynucleoside triphosphate triphosphohydrolase samhd1 (72 kDa, Protein from Homo sapiens)
- Water (18 Da, Ligand)
Cryo-EM structure of tetrameric human SAMHD1 State I - Tense
Resolution: 2.66 Å
EM Method: Single-particle
Fitted PDBs: 8qxk
Q-score: 0.62
Acton OJ, Sheppard D, Kunzelmann S, Caswell SJ, Nans A, Burgess AJO, Kelly G, Morris ER, Rosenthal PB, Taylor IA
Nat Commun (2024) 15 pp. 3775-3775 [ DOI: doi:10.1038/s41467-024-48237-w Pubmed: 38710701 ]
- Fe (iii) ion (55 Da, Ligand)
- Homotetramer of samhd1 (Complex from Homo sapiens)
- 2'-deoxycytidine-5'-triphosphate (467 Da, Ligand)
- Magnesium ion (24 Da, Ligand)
- Guanosine-5'-triphosphate (523 Da, Ligand)
- Deoxynucleoside triphosphate triphosphohydrolase samhd1 (72 kDa, Protein from Homo sapiens)
- 2'-deoxyadenosine 5'-triphosphate (491 Da, Ligand)
Cryo-EM structure of tetrameric human SAMHD1 State II - Hemi-relaxed
Resolution: 2.82 Å
EM Method: Single-particle
Fitted PDBs: 8qxl
Q-score: 0.541
Acton OJ, Sheppard D, Kunzelmann S, Caswell SJ, Nans A, Burgess AJO, Kelly G, Morris ER, Rosenthal PB, Taylor IA
Nat Commun (2024) 15 pp. 3775-3775 [ DOI: doi:10.1038/s41467-024-48237-w Pubmed: 38710701 ]
- Fe (iii) ion (55 Da, Ligand)
- Homotetramer of samhd1 (Complex from Homo sapiens)
- 2'-deoxycytidine-5'-triphosphate (467 Da, Ligand)
- Triphosphate (257 Da, Ligand)
- Magnesium ion (24 Da, Ligand)
- 2'-deoxycytidine (227 Da, Ligand)
- Guanosine-5'-triphosphate (523 Da, Ligand)
- Deoxynucleoside triphosphate triphosphohydrolase samhd1 (72 kDa, Protein from Homo sapiens)
- 2'-deoxyadenosine 5'-triphosphate (491 Da, Ligand)
Cryo-EM structure of tetrameric human SAMHD1 State III - Relaxed
Resolution: 2.94 Å
EM Method: Single-particle
Fitted PDBs: 8qxm
Q-score: 0.573
Acton OJ, Sheppard D, Kunzelmann S, Caswell SJ, Nans A, Burgess AJO, Kelly G, Morris ER, Rosenthal PB, Taylor IA
Nat Commun (2024) 15 pp. 3775-3775 [ DOI: doi:10.1038/s41467-024-48237-w Pubmed: 38710701 ]
- Fe (iii) ion (55 Da, Ligand)
- Homotetramer of samhd1 (Complex from Homo sapiens)
- 2'-deoxycytidine-5'-triphosphate (467 Da, Ligand)
- Magnesium ion (24 Da, Ligand)
- Guanosine-5'-triphosphate (523 Da, Ligand)
- Deoxynucleoside triphosphate triphosphohydrolase samhd1 (72 kDa, Protein from Homo sapiens)
- 2'-deoxyadenosine 5'-triphosphate (491 Da, Ligand)
Cryo-EM structure of tetrameric human SAMHD1 State IV - Depleted relaxed
Resolution: 2.98 Å
EM Method: Single-particle
Fitted PDBs: 8qxn
Q-score: 0.459
Acton OJ, Sheppard D, Kunzelmann S, Caswell SJ, Nans A, Burgess AJO, Kelly G, Morris ER, Rosenthal PB, Taylor IA
Nat Commun (2024) 15 pp. 3775-3775 [ DOI: doi:10.1038/s41467-024-48237-w Pubmed: 38710701 ]
- Fe (iii) ion (55 Da, Ligand)
- Homotetramer of samhd1 (Complex from Homo sapiens)
- 2'-deoxycytidine-5'-triphosphate (467 Da, Ligand)
- Magnesium ion (24 Da, Ligand)
- Guanosine-5'-triphosphate (523 Da, Ligand)
- Deoxynucleoside triphosphate triphosphohydrolase samhd1 (72 kDa, Protein from Homo sapiens)
- 2'-deoxyadenosine 5'-triphosphate (491 Da, Ligand)
Cryo-EM structure of tetrameric human SAMHD1 State V - Depleted relaxed
Resolution: 3.43 Å
EM Method: Single-particle
Fitted PDBs: 8qxo
Q-score: 0.417
Acton OJ, Sheppard D, Kunzelmann S, Caswell SJ, Nans A, Burgess AJO, Kelly G, Morris ER, Rosenthal PB, Taylor IA
Nat Commun (2024) 15 pp. 3775-3775 [ DOI: doi:10.1038/s41467-024-48237-w Pubmed: 38710701 ]
- Fe (iii) ion (55 Da, Ligand)
- Homotetramer of samhd1 (Complex from Homo sapiens)
- 2'-deoxycytidine-5'-triphosphate (467 Da, Ligand)
- Magnesium ion (24 Da, Ligand)
- Guanosine-5'-triphosphate (523 Da, Ligand)
- Deoxynucleoside triphosphate triphosphohydrolase samhd1 (72 kDa, Protein from Homo sapiens)
- 2'-deoxyadenosine 5'-triphosphate (491 Da, Ligand)
Resolution: 2.9 Å
EM Method: Single-particle
Fitted PDBs: 8ril
Q-score: 0.551
Human RAD52 open ring conformation
Resolution: 3.2 Å
EM Method: Single-particle
Fitted PDBs: 8rj3
Q-score: 0.325
Liang CC, Greenhough LA, Masino L, Maslen S, Bajrami I, Tuppi M, Skehel M, Taylor IA, West SC
Nature (2024) 629 pp. 697-703 [ DOI: doi:10.1038/s41586-024-07347-7 Pubmed: 38658755 ]
- Open ring conformation of human rad52 (Complex from Homo sapiens)
- Dna repair protein rad52 homolog (46 kDa, Protein from Homo sapiens)
Human RAD52 open ring - ssDNA complex
Resolution: 2.3 Å
EM Method: Single-particle
Fitted PDBs: 8rjw
Q-score: 0.512
Liang CC, Greenhough LA, Masino L, Maslen S, Bajrami I, Tuppi M, Skehel M, Taylor IA, West SC
Nature (2024) 629 pp. 697-703 [ DOI: doi:10.1038/s41586-024-07347-7 Pubmed: 38658755 ]
- Water (18 Da, Ligand)
- Ssdna (6 kDa, DNA from Homo sapiens)
- Dna repair protein rad52 homolog (46 kDa, Protein from Homo sapiens)
- Magnesium ion (24 Da, Ligand)
- Open ring conformation of human rad52 in complex with ssdna (Complex from Homo sapiens)
Human Replication protein A (RPA; trimeric core) - ssDNA complex
Resolution: 3.2 Å
EM Method: Single-particle
Fitted PDBs: 8rk2
Q-score: 0.436
Liang CC, Greenhough LA, Masino L, Maslen S, Bajrami I, Tuppi M, Skehel M, Taylor IA, West SC
Nature (2024) 629 pp. 697-703 [ DOI: doi:10.1038/s41586-024-07347-7 Pubmed: 38658755 ]
- Replication protein a 14 kda subunit (13 kDa, Protein from Homo sapiens)
- Open ring conformation of human rad52 in complex with ssdna (Complex from Homo sapiens)
- Replication protein a 70 kda dna-binding subunit, n-terminally processed (68 kDa, Protein from Homo sapiens)
- Replication protein a 32 kda subunit (29 kDa, Protein from Homo sapiens)