› 8rjw

Electron Microscopy
2.3Å resolution

Human RAD52 open ring - ssDNA complex

Released:
DOI: 10.2210/pdb8rjw/pdb
PDB entry 8rjw coloured by chain, front view.
PDB entry 8rjw coloured by chain, side view.
PDB entry 8rjw coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Mechanism of single-stranded DNA annealing by RAD52-RPA complex.
Liang CC, Greenhough LA, Masino L, Maslen S, Bajrami I, Tuppi M, Skehel M, Taylor IA, West SC
Nature (2024)
PMID: 38658755
Related structures: EMD-19253

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
hetero decamer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-243369 (preferred)
Entry contents:
1 distinct polypeptide molecule
1 distinct DNA molecule
Macromolecules (2 distinct):
DNA repair protein RAD52 homolog Chains: A, B, C, D, E, F, G, H, I
Molecule details ›
Chains: A, B, C, D, E, F, G, H, I
Length: 418 amino acids
Theoretical weight: 46.23 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P43351 (Residues: 1-418; Coverage: 100%)
Gene name: RAD52
Sequence domains: Rad52/22 family double-strand break repair protein
ssDNA Chain: J
Molecule details ›
Chain: J
Length: 23 nucleotides
Theoretical weight: 6.95 KDa
Source organism: Homo sapiens
Expression system: Not provided

Ligands and Environments

1 bound ligand:
Ligand MG 5 x MG
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 2.3Å
Relevant EMDB volumes: EMD-19253
Expression systems:
  • Escherichia coli
  • Not provided

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