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LRRC8A-BRIL:C Heteromer in GDN
Kern DM, Bleier J, Mukherjee S, Hill JM, Kossiakoff AA, Isacoff EY, Brohawn SG
bioRxiv (2022) [ Pubmed: 30775971 DOI: 10.1101/2022.07.31.502239 ]
Image sets:
LRRC8A-BRIL:C Heteromer in lipid nanodiscs
Kern DM, Bleier J, Mukherjee S, Hill JM, Kossiakoff AA, Isacoff EY, Brohawn SG
bioRxiv (2022) [ Pubmed: 30775971 DOI: 10.1101/2022.07.31.502239 ]
Image sets:
LRRC8A-BRIL(T48D):C Heteromer in GDN
Kern DM, Bleier J, Mukherjee S, Hill JM, Kossiakoff AA, Isacoff EY, Brohawn SG
bioRxiv (2022) [ Pubmed: 30775971 DOI: 10.1101/2022.07.31.502239 ]
Image sets:
LRRC8A:C conformation 2 (oblong) top mask
Resolution: 3.04 Å
EM Method: Single-particle
Fitted PDBs: 8dr8
Q-score: 0.463
Kern DM, Bleier J, Mukherjee S, Hill JM, Kossiakoff AA, Isacoff EY, Brohawn SG
Nat Struct Mol Biol (2023) 30 pp. 841-852 [ Pubmed: 36928458 DOI: doi:10.1038/s41594-023-00944-6 ]
- Water (18 Da, Ligand)
- Lrrc8a:c (620 kDa, Complex from Mus musculus)
- Volume-regulated anion channel subunit lrrc8a,soluble cytochrome b562 (105 kDa, Protein from Mus musculus)
- Volume-regulated anion channel subunit lrrc8c (93 kDa, Protein from Mus musculus)
- 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine (744 Da, Ligand)
LRRC8A:C conformation 2 (oblong) LRR mask
Resolution: 3.98 Å
EM Method: Single-particle
Fitted PDBs: 8dra
Q-score: 0.281
Kern DM, Bleier J, Mukherjee S, Hill JM, Kossiakoff AA, Isacoff EY, Brohawn SG
Nat Struct Mol Biol (2023) 30 pp. 841-852 [ Pubmed: 36928458 DOI: doi:10.1038/s41594-023-00944-6 ]
- Volume-regulated anion channel subunit lrrc8c (93 kDa, Protein from Mus musculus)
- Volume-regulated anion channel subunit lrrc8a,soluble cytochrome b562 (105 kDa, Protein from Mus musculus)
- Lrrc8a:c (620 kDa, Complex from Mus musculus)
LRRC8A:C conformation 2 (oblong)
Resolution: 3.18 Å
EM Method: Single-particle
Fitted PDBs: 8dre
Q-score: 0.382
Kern DM, Bleier J, Mukherjee S, Hill JM, Kossiakoff AA, Isacoff EY, Brohawn SG
Nat Struct Mol Biol (2023) 30 pp. 841-852 [ Pubmed: 36928458 DOI: doi:10.1038/s41594-023-00944-6 ]
- Water (18 Da, Ligand)
- Lrrc8a:c (620 kDa, Complex from Mus musculus)
- Volume-regulated anion channel subunit lrrc8a,soluble cytochrome b562 (105 kDa, Protein from Mus musculus)
- Volume-regulated anion channel subunit lrrc8c (93 kDa, Protein from Mus musculus)
- 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine (744 Da, Ligand)
LRRC8A:C conformation 1 (round) top focus
Resolution: 2.95 Å
EM Method: Single-particle
Fitted PDBs: 8drk
Q-score: 0.47
Kern DM, Bleier J, Mukherjee S, Hill JM, Kossiakoff AA, Isacoff EY, Brohawn SG
Nat Struct Mol Biol (2023) 30 pp. 841-852 [ Pubmed: 36928458 DOI: doi:10.1038/s41594-023-00944-6 ]
- Water (18 Da, Ligand)
- Lrrc8a:c (620 kDa, Complex from Mus musculus)
- Volume-regulated anion channel subunit lrrc8a,soluble cytochrome b562 (105 kDa, Protein from Mus musculus)
- Volume-regulated anion channel subunit lrrc8c (93 kDa, Protein from Mus musculus)
- 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine (744 Da, Ligand)
LRRC8A:C conformation 1 (round) LRR focus 1
Resolution: 4.12 Å
EM Method: Single-particle
Fitted PDBs: 8drn
Q-score: 0.258
Kern DM, Bleier J, Mukherjee S, Hill JM, Kossiakoff AA, Isacoff EY, Brohawn SG
Nat Struct Mol Biol (2023) 30 pp. 841-852 [ Pubmed: 36928458 DOI: doi:10.1038/s41594-023-00944-6 ]
- Volume-regulated anion channel subunit lrrc8c (93 kDa, Protein from Mus musculus)
- Volume-regulated anion channel subunit lrrc8a,soluble cytochrome b562 (105 kDa, Protein from Mus musculus)
- Lrrc8a:c (620 kDa, Complex from Mus musculus)
LRRC8A:C conformation 1 (round) LRR focus 2
Resolution: 4.06 Å
EM Method: Single-particle
Fitted PDBs: 8dro
Q-score: 0.156
Kern DM, Bleier J, Mukherjee S, Hill JM, Kossiakoff AA, Isacoff EY, Brohawn SG
Nat Struct Mol Biol (2023) 30 pp. 841-852 [ Pubmed: 36928458 DOI: doi:10.1038/s41594-023-00944-6 ]
- Volume-regulated anion channel subunit lrrc8a,soluble cytochrome b562 (105 kDa, Protein from Mus musculus)
- Lrrc8a:c (620 kDa, Complex from Mus musculus)
LRRC8A:C conformation 1 (round) LRR focus 3
Resolution: 4.16 Å
EM Method: Single-particle
Fitted PDBs: 8drq
Q-score: 0.158
Kern DM, Bleier J, Mukherjee S, Hill JM, Kossiakoff AA, Isacoff EY, Brohawn SG
Nat Struct Mol Biol (2023) 30 pp. 841-852 [ Pubmed: 36928458 DOI: doi:10.1038/s41594-023-00944-6 ]
- Volume-regulated anion channel subunit lrrc8a,soluble cytochrome b562 (105 kDa, Protein from Mus musculus)
- Lrrc8a:c (620 kDa, Complex from Mus musculus)