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CryoEM structure of NaDC1 with Citrate
Resolution: 2.7 Å
EM Method: Single-particle
Fitted PDBs: 8w6c
Q-score: 0.631
Chi X, Chen Y, Li Y, Dai L, Zhang Y, Shen Y, Chen Y, Shi T, Yang H, Wang Z, Yan R
Sci Adv (2024) 10 pp. eadl3685-eadl3685 [ Pubmed: 38552027 DOI: doi:10.1126/sciadv.adl3685 ]
- Sodium ion (22 Da, Ligand)
- Structure of nadc1 in complex with citrate (Complex from Homo sapiens)
- Citric acid (192 Da, Ligand)
- 1,2-diacyl-glycerol-3-sn-phosphate (704 Da, Ligand)
- Cholesterol hemisuccinate (486 Da, Ligand)
- Solute carrier family 13 member 2 (65 kDa, Protein from Homo sapiens)
- Water (18 Da, Ligand)
CryoEM structure of NaDC1 in apo state
Resolution: 2.5 Å
EM Method: Single-particle
Fitted PDBs: 8w6d
Q-score: 0.662
Chi X, Chen Y, Li Y, Dai L, Zhang Y, Shen Y, Chen Y, Shi T, Yang H, Wang Z, Yan R
Sci Adv (2024) 10 pp. eadl3685-eadl3685 [ Pubmed: 38552027 DOI: doi:10.1126/sciadv.adl3685 ]
- Sodium ion (22 Da, Ligand)
- 1,2-diacyl-glycerol-3-sn-phosphate (704 Da, Ligand)
- Cholesterol hemisuccinate (486 Da, Ligand)
- Solute carrier family 13 member 2 (65 kDa, Protein from Homo sapiens)
- Structure of nadc1 in apo state (Complex from Homo sapiens)
Resolution: 3.3 Å
EM Method: Single-particle
Fitted PDBs: 8w6g
Q-score: 0.552
Chi X, Chen Y, Li Y, Dai L, Zhang Y, Shen Y, Chen Y, Shi T, Yang H, Wang Z, Yan R
Sci Adv (2024) 10 pp. eadl3685-eadl3685 [ Pubmed: 38552027 DOI: doi:10.1126/sciadv.adl3685 ]
- 1,2-diacyl-glycerol-3-sn-phosphate (704 Da, Ligand)
- Nadc1 in complex with inhibitor n-(p-amylcinnamoyl)anthranilic acid (aca) (Complex from Homo sapiens)
- Cholesterol hemisuccinate (486 Da, Ligand)
- Solute carrier family 13 member 2 (65 kDa, Protein from Homo sapiens)
- 2-[[(~{e})-3-(4-pentylphenyl)prop-2-enoyl]amino]benzoic acid (337 Da, Ligand)
NaS1 with sulfate - IN/IN state
Resolution: 3.1 Å
EM Method: Single-particle
Fitted PDBs: 8w6h
Q-score: 0.567
Chi X, Chen Y, Li Y, Dai L, Zhang Y, Shen Y, Chen Y, Shi T, Yang H, Wang Z, Yan R
Sci Adv (2024) 10 pp. eadl3685-eadl3685 [ Pubmed: 38552027 DOI: doi:10.1126/sciadv.adl3685 ]
- Sodium ion (22 Da, Ligand)
- Sulfate ion (96 Da, Ligand)
- Cholesterol (386 Da, Ligand)
- Dimer of nas1 with sulfate in in/in state (Complex from Homo sapiens)
- Solute carrier family 13 member 1 (67 kDa, Protein from Homo sapiens)
NaS1 with sulfate in IN/OUT state
Resolution: 3.2 Å
EM Method: Single-particle
Fitted PDBs: 8w6n
Q-score: 0.536
Chi X, Chen Y, Li Y, Dai L, Zhang Y, Shen Y, Chen Y, Shi T, Yang H, Wang Z, Yan R
Sci Adv (2024) 10 pp. eadl3685-eadl3685 [ Pubmed: 38552027 DOI: doi:10.1126/sciadv.adl3685 ]
- Sodium ion (22 Da, Ligand)
- Sulfate ion (96 Da, Ligand)
- Structure of nas1 in complex with sulfate (Complex from Homo sapiens)
- Solute carrier family 13 member 1 (67 kDa, Protein from Homo sapiens)
Resolution: 2.9 Å
EM Method: Single-particle
Fitted PDBs: 8w6o
Q-score: 0.58
Chi X, Chen Y, Li Y, Dai L, Zhang Y, Shen Y, Chen Y, Shi T, Yang H, Wang Z, Yan R
Sci Adv (2024) 10 pp. eadl3685-eadl3685 [ Pubmed: 38552027 DOI: doi:10.1126/sciadv.adl3685 ]
- Sodium ion (22 Da, Ligand)
- Dimer of nas1 in in/in state (Complex from Homo sapiens)
- Cholesterol (386 Da, Ligand)
- Solute carrier family 13 member 1 (67 kDa, Protein from Homo sapiens)
Resolution: 3.0 Å
EM Method: Single-particle
Fitted PDBs: 8w6t
Q-score: 0.54
Chi X, Chen Y, Li Y, Dai L, Zhang Y, Shen Y, Chen Y, Shi T, Yang H, Wang Z, Yan R
Sci Adv (2024) 10 pp. eadl3685-eadl3685 [ Pubmed: 38552027 DOI: doi:10.1126/sciadv.adl3685 ]
- Solute carrier family 13 member 1 (67 kDa, Protein from Homo sapiens)
- Dimer of nas1 in in/out state (Complex from Homo sapiens)
ACE2-SIT1 complex bound with proline
Resolution: 3.3 Å
EM Method: Single-particle
Fitted PDBs: 8i91
Q-score: 0.367
Li Y, Chen Y, Zhang Y, Shen Y, Xu K, Liu Y, Wang Z, Yan R
Cell Discov (2023) 9 pp. 93-93 [ Pubmed: 37684251 DOI: doi:10.1038/s41421-023-00596-2 ]
- Chloride ion (35 Da, Ligand)
- Proline (115 Da, Ligand)
- Angiotensin-converting enzyme 2 (95 kDa, Protein from Homo sapiens)
- Sit1 (68 kDa, Protein from Homo sapiens)
- Ace2-sit1 complex bound with proline (Complex from Homo sapiens)
- Zinc ion (65 Da, Ligand)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
ACE2-B0AT1 complex bound with glutamine
Resolution: 3.2 Å
EM Method: Single-particle
Fitted PDBs: 8i92
Q-score: 0.452
Li Y, Chen Y, Zhang Y, Shen Y, Xu K, Liu Y, Wang Z, Yan R
Cell Discov (2023) 9 pp. 93-93 [ Pubmed: 37684251 DOI: doi:10.1038/s41421-023-00596-2 ]
- Angiotensin-converting enzyme 2 (95 kDa, Protein from Homo sapiens)
- Sodium-dependent neutral amino acid transporter b(0)at1 (68 kDa, Protein from Homo sapiens)
- Glutamine (146 Da, Ligand)
- Ace2-b0at1 complex bound with glutamine (Complex from Homo sapiens)
- Zinc ion (65 Da, Ligand)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
ACE2-B0AT1 complex bound with methionine
Resolution: 3.1 Å
EM Method: Single-particle
Fitted PDBs: 8i93
Q-score: 0.474
Li Y, Chen Y, Zhang Y, Shen Y, Xu K, Liu Y, Wang Z, Yan R
Cell Discov (2023) 9 pp. 93-93 [ Pubmed: 37684251 DOI: doi:10.1038/s41421-023-00596-2 ]
- Sodium-dependent neutral amino acid transporter b(0)at1 (73 kDa, Protein from Homo sapiens)
- Methionine (149 Da, Ligand)
- Angiotensin-converting enzyme 2 (86 kDa, Protein from Homo sapiens)
- Zinc ion (65 Da, Ligand)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Ace2-b0at1 complex bound with methionine (Complex from Homo sapiens)