› 8w6n

Electron Microscopy
3.2Å resolution

NaS1 with sulfate in IN/OUT state

Released:
DOI: 10.2210/pdb8w6n/pdb
PDB entry 8w6n coloured by chain, front view.
PDB entry 8w6n coloured by chain, side view.
PDB entry 8w6n coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Cryo-EM structures of the human NaS1 and NaDC1 transporters revealed the elevator transport and allosteric regulation mechanism.
Chi X, Chen Y, Li Y, Dai L, Zhang Y, Shen Y, Chen Y, Shi T, Yang H, Wang Z, Yan R
Sci Adv 10 eadl3685 (2024)
PMID: 38552027
Related structures: EMD-37329

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-243214 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Solute carrier family 13 member 1 Chains: A, B
Molecule details ›
Chains: A, B
Length: 608 amino acids
Theoretical weight: 67.69 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: Q9BZW2 (Residues: 1-595; Coverage: 100%)
Gene names: NAS1, NASI1, SLC13A1
Sequence domains: Sodium:sulfate symporter transmembrane region

Ligands and Environments

2 bound ligands:
Ligand SO4 2 x SO4
Ligand NA 1 x NA
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 3.2Å
Relevant EMDB volumes: EMD-37329
Expression system: Homo sapiens

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