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Cryo-EM structure of the glucagon receptor bound to beta-arrestin 1 in ligand-free state
Resolution: 3.5 Å
EM Method: Single-particle
Fitted PDBs: 8jru
Q-score: 0.438
Chen K, Zhang C, Lin S, Yan X, Cai H, Yi C, Ma L, Chu X, Liu Y, Zhu Y, Han S, Zhao Q, Wu B
Nature (2023) 620 pp. 904-910 [ Pubmed: 37558880 DOI: doi:10.1038/s41586-023-06420-x ]
- The glucagon receptor bound to beta-arrestin 1 (Complex from Homo sapiens)
- Nanobody 32 (13 kDa, Protein from Escherichia phage EcSzw-2)
- Beta-arrestin 1 and single-chain fragment variable 30 (scfv30) (69 kDa, Protein from Bos taurus)
- [(2r)-2-octanoyloxy-3-[oxidanyl-[(1r,2r,3s,4r,5r,6s)-2,3,6-tris(oxidanyl)-4,5-diphosphonooxy-cyclohexyl]oxy-phosphoryl]oxy-propyl] octanoate (746 Da, Ligand)
- Ha signal peptide,hpc4 purification tag,glucagon receptor,c-terminal tail of vasopressin v2 receptor (54 kDa, Protein from Homo sapiens)
Cryo-EM structure of the glucagon receptor bound to glucagon and beta-arrestin 1
Resolution: 3.3 Å
EM Method: Single-particle
Fitted PDBs: 8jrv
Q-score: 0.431
Chen K, Zhang C, Lin S, Yan X, Cai H, Yi C, Ma L, Chu X, Liu Y, Zhu Y, Han S, Zhao Q, Wu B
Nature (2023) 620 pp. 904-910 [ Pubmed: 37558880 DOI: doi:10.1038/s41586-023-06420-x ]
- Beta-arrestin 1 and single-chain fragment variable 30 (scfv30) (69 kDa, Protein from Homo sapiens)
- The glucagon receptor bound to glucagon and beta-arrestin 1 (Complex from Homo sapiens)
- Nanobody 32 (13 kDa, Protein from Escherichia phage EcSzw-2)
- Glucagon (3 kDa, Protein from Homo sapiens)
- [(2r)-2-octanoyloxy-3-[oxidanyl-[(1r,2r,3s,4r,5r,6s)-2,3,6-tris(oxidanyl)-4,5-diphosphonooxy-cyclohexyl]oxy-phosphoryl]oxy-propyl] octanoate (746 Da, Ligand)
- Ha signal peptide,hpc4 purification tag,glucagon receptor,c-terminal tail of vasopressin v2 receptor (54 kDa, Protein from Homo sapiens)
Resolution: 3.29 Å
EM Method: Single-particle
Fitted PDBs: 7wn3
Q-score: 0.295
Shu Z, Zeng J, Xia L, Cai H, Zhou A
Cell Discov (2022) 8 pp. 14-14 [ Pubmed: 35169124 DOI: doi:10.1038/s41421-022-00378-2 ]
- Von willebrand factor (54 kDa, Protein from Homo sapiens)
- Calcium ion (40 Da, Ligand)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Von willebrand antigen 2 (81 kDa, Protein from Homo sapiens)
- Vwf d'd3-d1d2 complex (1 unit) (Complex from Homo sapiens)
Resolution: 3.4 Å
EM Method: Single-particle
Fitted PDBs: 7wn4
Q-score: 0.508
Shu Z, Zeng J, Xia L, Cai H, Zhou A
Cell Discov (2022) 8 pp. 14-14 [ Pubmed: 35169124 DOI: doi:10.1038/s41421-022-00378-2 ]
- Calcium ion (40 Da, Ligand)
- Von willebrand factor (54 kDa, Protein from Homo sapiens)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Von willebrand antigen 2 (81 kDa, Protein from Homo sapiens)
- Vwf d'd3-d1d2 complex (1 unit) (Complex from Homo sapiens)
Resolution: 3.29 Å
EM Method: Single-particle
Fitted PDBs: 7wn6
Q-score: 0.295
Shu Z, Zeng J, Xia L, Cai H, Zhou A
Cell Discov (2022) 8 pp. 14-14 [ Pubmed: 35169124 DOI: doi:10.1038/s41421-022-00378-2 ]
- Von willebrand factor (54 kDa, Protein from Homo sapiens)
- Calcium ion (40 Da, Ligand)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Von willebrand antigen 2 (81 kDa, Protein from Homo sapiens)
- Vwf d'd3-d1d2 complex (1 unit) (Complex from Homo sapiens)