Do data resources managed by EMBL-EBI and our collaborators make a difference to your work? Please take 10 minutes to fill in our annual user survey, and help us make the case for why sustaining open data resources is critical for life sciences research.
Cytoplasmic dynein-1 motor domain bound to dynactin-p150glued and LIS1
Resolution: 4.2 Å
EM Method: Single-particle
Fitted PDBs: 8pqw
Q-score: 0.342
Singh K, Lau CK, Manigrasso G, Gama JB, Gassmann R, Carter AP
Science (2024) 383 pp. eadk8544-eadk8544 [ Pubmed: 38547289 DOI: doi:10.1126/science.adk8544 ]
- Adenosine-5'-diphosphate (427 Da, Ligand)
- Cytoplasmic dynein 1 intermediate chain 2 (68 kDa, Protein from Homo sapiens)
- Cytoplasmic dynein 1 heavy chain 1 (533 kDa, Protein from Homo sapiens)
- Cytoplasmic dynein-1 bound to dynactin p150 and lis1 (Complex from Homo sapiens)
- Dynactin subunit 1 (142 kDa, Protein from Sus scrofa)
- Magnesium ion (24 Da, Ligand)
- Platelet-activating factor acetylhydrolase ib subunit beta (46 kDa, Protein from Homo sapiens)
- Adenosine-5'-triphosphate (507 Da, Ligand)
Cytoplasmic dynein-1 A1/A2 motor domains bound to LIS1
Resolution: 5.5 Å
EM Method: Single-particle
Fitted PDBs: 8pqz
Q-score: 0.284
Singh K, Lau CK, Manigrasso G, Gama JB, Gassmann R, Carter AP
Science (2024) 383 pp. eadk8544-eadk8544 [ Pubmed: 38547289 DOI: doi:10.1126/science.adk8544 ]
- Adenosine-5'-diphosphate (427 Da, Ligand)
- Cytoplasmic dynein 1 intermediate chain 2 (68 kDa, Protein from Homo sapiens)
- Cytoplasmic dynein 1 heavy chain 1 (533 kDa, Protein from Homo sapiens)
- Dynactin subunit 1 (142 kDa, Protein from Sus scrofa)
- Magnesium ion (24 Da, Ligand)
- Cytoplasmic dynein-a1/a2 motor domains bound to lis1 (Complex from Homo sapiens)
- Platelet-activating factor acetylhydrolase ib subunit beta (46 kDa, Protein from Homo sapiens)
- Adenosine-5'-triphosphate (507 Da, Ligand)
Cytoplasmic dynein-A heavy chain bound to dynactin-p150glued and IC-LC tower
Resolution: 9.4 Å
EM Method: Single-particle
Fitted PDBs: 8pr0
Q-score: 0.169
Singh K, Lau CK, Manigrasso G, Gama JB, Gassmann R, Carter AP
Science (2024) 383 pp. eadk8544-eadk8544 [ Pubmed: 38547289 DOI: doi:10.1126/science.adk8544 ]
- Cytoplasmic dynein 1 light intermediate chain 2 (54 kDa, Protein from Homo sapiens)
- Cytoplasmic dynein 1 intermediate chain 2 (68 kDa, Protein from Homo sapiens)
- Cytoplasmic dynein 1 heavy chain 1 (533 kDa, Protein from Homo sapiens)
- Dynactin subunit 1 (142 kDa, Protein from Sus scrofa)
- Cytoplasmic dynein-a heavy chain bound to dynactin p150 and ic-lc tower (Complex from Homo sapiens)
- Dynein light chain tctex-type 1 (12 kDa, Protein from Homo sapiens)
- Dynein light chain 1, cytoplasmic (10 kDa, Protein from Homo sapiens)
Resolution: 3.75 Å
EM Method: Single-particle
Fitted PDBs: 8ouw
Q-score: 0.329
Xia Y, Sonneville R, Jenkyn-Bedford M, Ji L, Alabert C, Hong Y, Yeeles JTP, Labib KPM
Science (2023) 381 pp. eadi4932-eadi4932 [ Pubmed: 37590372 DOI: doi:10.1126/science.adi4932 ]
- Cell division control protein 45 homolog (66 kDa, Protein from Caenorhabditis elegans)
- Dna replication licensing factor mcm-6 (91 kDa, Protein from Caenorhabditis elegans)
- Dna lagging strand template (18 kDa, DNA from Saccharomyces cerevisiae)
- Probable dna replication complex gins protein psf2 (20 kDa, Protein from Caenorhabditis elegans)
- Zinc ion (65 Da, Ligand)
- Dna replication licensing factor mcm2 (99 kDa, Protein from Caenorhabditis elegans)
- Dna replication licensing factor mcm3 (90 kDa, Protein from Caenorhabditis elegans)
- Dna leading strand template (26 kDa, DNA from Saccharomyces cerevisiae)
- Dna replication licensing factor mcm-4 (91 kDa, Protein from Caenorhabditis elegans)
- Protein tipin homolog (27 kDa, Protein from Caenorhabditis elegans)
- Downstream neighbor of son homolog (66 kDa, Protein from Caenorhabditis elegans)
- Dna replication licensing factor mcm-5 (85 kDa, Protein from Caenorhabditis elegans)
- Probable dna replication complex gins protein psf1 (23 kDa, Protein from Caenorhabditis elegans)
- Dna replication complex gins protein sld5 (25 kDa, Protein from Caenorhabditis elegans)
- Dna replication licensing factor mcm7 (81 kDa, Protein from Caenorhabditis elegans)
- Dna replication complex gins protein psf3 (21 kDa, Protein from Caenorhabditis elegans)
- Magnesium ion (24 Da, Ligand)
- Phosphoaminophosphonic acid-adenylate ester (506 Da, Ligand)
- Complex of cmg helicase bound to tim-1/tipn-1 and homodimeric dnsn-1 on fork dna (caenorhabditis elegans) (Complex from Caenorhabditis elegans)
- Protein timeless homolog (157 kDa, Protein from Caenorhabditis elegans)
Human Mediator (deletion of MED1-IDR) in a Tail-bent conformation (MED-B)
Resolution: 4.4 Å
EM Method: Single-particle
Fitted PDBs: 7enj
Q-score: 0.17
Chen X, Yin X, Li J, Wu Z, Qi Y, Wang X, Liu W, Xu Y
Science (2021) 372 [ DOI: doi:10.1126/science.abg0635 Pubmed: 33958484 ]
- Mediator of rna polymerase ii transcription subunit 16 (96 kDa, Protein from Homo sapiens)
- Mediator of rna polymerase ii transcription subunit 7 (27 kDa, Protein from Homo sapiens)
- Mediator of rna polymerase ii transcription subunit 17 (72 kDa, Protein from Homo sapiens)
- Mediator of rna polymerase ii transcription subunit 1 (168 kDa, Protein from Homo sapiens)
- Zinc ion (65 Da, Ligand)
- Mediator of rna polymerase ii transcription subunit 21 (15 kDa, Protein from Homo sapiens)
- Mediator of rna polymerase ii transcription subunit 22 (22 kDa, Protein from Homo sapiens)
- Mediator of rna polymerase ii transcription subunit 27 (35 kDa, Protein from Homo sapiens)
- Isoform 2 of mediator of rna polymerase ii transcription subunit 8 (29 kDa, Protein from Homo sapiens)
- Unknown chain (1 kDa, Protein from Homo sapiens)
- Mediator of rna polymerase ii transcription subunit 14 (160 kDa, Protein from Homo sapiens)
- Mediator of rna polymerase ii transcription subunit 31 (15 kDa, Protein from Homo sapiens)
- Mediator of rna polymerase ii transcription subunit 6 (28 kDa, Protein from Homo sapiens)
- Mediator of rna polymerase ii transcription subunit 19 (26 kDa, Protein from Homo sapiens)
- Mediator of rna polymerase ii transcription subunit 4 (29 kDa, Protein from Homo sapiens)
- Mediator of rna polymerase ii transcription subunit 18 (23 kDa, Protein from Homo sapiens)
- Mediator of rna polymerase ii transcription subunit 23 (156 kDa, Protein from Homo sapiens)
- Structure of the human mediator complex (Complex from Homo sapiens)
- Mediator of rna polymerase ii transcription subunit 20 (23 kDa, Protein from Homo sapiens)
- Mediator of rna polymerase ii transcription subunit 29 (21 kDa, Protein from Homo sapiens)
- Mediator of rna polymerase ii transcription subunit 9 (16 kDa, Protein from Homo sapiens)
- Mediator of rna polymerase ii transcription subunit 28 (19 kDa, Protein from Homo sapiens)
- Mediator of rna polymerase ii transcription subunit 10 (15 kDa, Protein from Homo sapiens)
- Mediator of rna polymerase ii transcription subunit 26 (65 kDa, Protein from Homo sapiens)
- Mediator of rna polymerase ii transcription subunit 30 (20 kDa, Protein from Homo sapiens)
- Mediator of rna polymerase ii transcription subunit 11 (13 kDa, Protein from Homo sapiens)
- Mediator of rna polymerase ii transcription subunit 15 (86 kDa, Protein from Homo sapiens)
- Mediator of rna polymerase ii transcription subunit 24 (110 kDa, Protein from Homo sapiens)
Human Mediator (deletion of MED1-IDR) in a Tail-extended conformation
Resolution: 3.5 Å
EM Method: Single-particle
Fitted PDBs: 7emf
Q-score: 0.331
Chen X, Yin X, Li J, Wu Z, Qi Y, Wang X, Liu W, Xu Y
Science (2021) 372 [ DOI: doi:10.1126/science.abg0635 Pubmed: 33958484 ]
- Mediator of rna polymerase ii transcription subunit 7 (27 kDa, Protein from Homo sapiens)
- Mediator of rna polymerase ii transcription subunit 17 (72 kDa, Protein from Homo sapiens)
- Mediator of rna polymerase ii transcription subunit 1 (168 kDa, Protein from Homo sapiens)
- Zinc ion (65 Da, Ligand)
- Mediator of rna polymerase ii transcription subunit 21 (15 kDa, Protein from Homo sapiens)
- Mediator of rna polymerase ii transcription subunit 22 (22 kDa, Protein from Homo sapiens)
- Mediator of rna polymerase ii transcription subunit 27 (35 kDa, Protein from Homo sapiens)
- Isoform 2 of mediator of rna polymerase ii transcription subunit 8 (29 kDa, Protein from Homo sapiens)
- Mediator of rna polymerase ii transcription subunit 14 (160 kDa, Protein from Homo sapiens)
- Isoform 2 of mediator of rna polymerase ii transcription subunit 16 (93 kDa, Protein from Homo sapiens)
- Mediator of rna polymerase ii transcription subunit 31 (15 kDa, Protein from Homo sapiens)
- Mediator of rna polymerase ii transcription subunit 6 (28 kDa, Protein from Homo sapiens)
- Mediator of rna polymerase ii transcription subunit 19 (26 kDa, Protein from Homo sapiens)
- Mediator of rna polymerase ii transcription subunit 4 (29 kDa, Protein from Homo sapiens)
- Mediator of rna polymerase ii transcription subunit 18 (23 kDa, Protein from Homo sapiens)
- Mediator of rna polymerase ii transcription subunit 23 (156 kDa, Protein from Homo sapiens)
- Structure of the human mediator complex (Complex from Homo sapiens)
- Mediator of rna polymerase ii transcription subunit 20 (23 kDa, Protein from Homo sapiens)
- Mediator of rna polymerase ii transcription subunit 29 (21 kDa, Protein from Homo sapiens)
- Mediator of rna polymerase ii transcription subunit 25 (78 kDa, Protein from Homo sapiens)
- Mediator of rna polymerase ii transcription subunit 9 (16 kDa, Protein from Homo sapiens)
- Mediator of rna polymerase ii transcription subunit 28 (19 kDa, Protein from Homo sapiens)
- Mediator of rna polymerase ii transcription subunit 10 (15 kDa, Protein from Homo sapiens)
- Mediator of rna polymerase ii transcription subunit 26 (65 kDa, Protein from Homo sapiens)
- Mediator of rna polymerase ii transcription subunit 30 (20 kDa, Protein from Homo sapiens)
- Unknown chain (poly a) (1 kDa, Protein from Homo sapiens)
- Mediator of rna polymerase ii transcription subunit 11 (13 kDa, Protein from Homo sapiens)
- Mediator of rna polymerase ii transcription subunit 15 (86 kDa, Protein from Homo sapiens)
- Mediator of rna polymerase ii transcription subunit 24 (110 kDa, Protein from Homo sapiens)