8pr0

Electron Microscopy
9.4Å resolution

Cytoplasmic dynein-A heavy chain bound to dynactin-p150glued and IC-LC tower

Released:
Source organisms:
Related structures: EMD-17830

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:

Structure analysis Details

Assembly composition:
hetero undecamer (preferred)
PDBe Complex ID:
PDB-CPX-242097 (preferred)
Entry contents:
6 distinct polypeptide molecules
Macromolecules (6 distinct):
Cytoplasmic dynein 1 intermediate chain 2 Chains: C, D
Molecule details ›
Chains: C, D
Length: 612 amino acids
Theoretical weight: 68.44 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: Q13409 (Residues: 1-638; Coverage: 96%)
Gene names: DNCI2, DNCIC2, DYNC1I2
Sequence domains:
Dynein light chain 1, cytoplasmic Chains: E, F
Molecule details ›
Chains: E, F
Length: 89 amino acids
Theoretical weight: 10.38 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: P63167 (Residues: 1-89; Coverage: 100%)
Gene names: DLC1, DNCL1, DNCLC1, DYNLL1, HDLC1
Sequence domains: Dynein light chain type 1
Dynein light chain Tctex-type 1 Chains: G, H
Molecule details ›
Chains: G, H
Length: 113 amino acids
Theoretical weight: 12.46 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: P63172 (Residues: 1-113; Coverage: 100%)
Gene names: DYNLT1, TCTEL1, TCTEX-1, TCTEX1
Sequence domains: Tctex-1 family
Dynactin subunit 1 Chains: I, J
Molecule details ›
Chains: I, J
Length: 1281 amino acids
Theoretical weight: 142.02 KDa
Source organism: Sus scrofa
UniProt:
  • Canonical: A0A287B8J2 (Residues: 1-1281; Coverage: 100%)
Gene name: DCTN1
Sequence domains:
Cytoplasmic dynein 1 light intermediate chain 2 Chain: K
Molecule details ›
Chain: K
Length: 492 amino acids
Theoretical weight: 54.17 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: O43237 (Residues: 1-492; Coverage: 100%)
Gene names: DNCLI2, DYNC1LI2, LIC2
Sequence domains: Dynein light intermediate chain (DLIC)

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 9.4Å
Relevant EMDB volumes: EMD-17830
Expression system: Spodoptera frugiperda