CHEBI:167693 - GSK343

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ChEBI Name GSK343
ChEBI ID CHEBI:167693
Definition A member of the class of indazoles that is 1-isopropyl-1H-indazole-4-carboxamide in which the nitrogen of the carboxamide group is substituted by a (6-methyl-2-oxo-4-propyl-1,2-dihydropyridin-3-yl)methyl group and in which the indazole ring is substituted at position 6 by a 2-(4-methylpiperazin-1-yl)pyridin-4-yl group. A highly potent and selective EZH2 inhibitor (IC50 = 4 nM).
Stars This entity has been manually annotated by the ChEBI Team.
Supplier Information
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Formula C31H39N7O2
Net Charge 0
Average Mass 541.700
Monoisotopic Mass 541.31652
InChI InChI=1S/C31H39N7O2/c1-6-7-23-14-21(4)35-31(40)26(23)18-33-30(39)25-15-24(16-28-27(25)19-34-38(28)20(2)3)22-8-9-32-29(17-22)37-12-10-36(5)11-13-37/h8-9,14-17,19-20H,6-7,10-13,18H2,1-5H3,(H,33,39)(H,35,40)
InChIKey ULNXAWLQFZMIHX-UHFFFAOYSA-N
SMILES CCCC1=C(CNC(=O)C2=CC(=CC3=C2C=NN3C(C)C)C2=CC=NC(=C2)N2CCN(C)CC2)C(=O)NC(C)=C1
Roles Classification
Chemical Role(s): Bronsted base
A molecular entity capable of accepting a hydron from a donor (Bronsted acid).
(via organic amino compound )
Biological Role(s): EC 2.1.1.43 (enhancer of zeste homolog 2) inhibitor
An EC 2.1.1.* (methyltransferases) inhibitor that interferes with the action of Enhancer of zeste homolog 2 (EZH2), a histone-lysine N-methyltransferase (EC 2.1.1.43).
apoptosis inducer
Any substance that induces the process of apoptosis (programmed cell death) in multi-celled organisms.
Application(s): antineoplastic agent
A substance that inhibits or prevents the proliferation of neoplasms.
View more via ChEBI Ontology
ChEBI Ontology
Outgoing GSK343 (CHEBI:167693) has role antineoplastic agent (CHEBI:35610)
GSK343 (CHEBI:167693) has role apoptosis inducer (CHEBI:68495)
GSK343 (CHEBI:167693) has role EC 2.1.1.43 (enhancer of zeste homolog 2) inhibitor (CHEBI:167694)
GSK343 (CHEBI:167693) is a N-alkylpiperazine (CHEBI:46845)
GSK343 (CHEBI:167693) is a N-arylpiperazine (CHEBI:46848)
GSK343 (CHEBI:167693) is a aminopyridine (CHEBI:38207)
GSK343 (CHEBI:167693) is a indazoles (CHEBI:38769)
GSK343 (CHEBI:167693) is a pyridone (CHEBI:38183)
GSK343 (CHEBI:167693) is a secondary carboxamide (CHEBI:140325)
IUPAC Name
1-isopropyl-N-[(6-methyl-2-oxo-4-propyl-1,2-dihydropyridin-3-yl)methyl]-6-[2-(4-methylpiperazin-1-yl)pyridin-4-yl]-1H-indazole-4-carboxamide
Synonyms Sources
GSK 343 ChEBI
GSK-343 ChEBI
Manual Xref Database
CA2798622 Patent
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Registry Number Type Source
1346704-33-3 CAS Registry Number ChEBI
Citations Waiting for Citations Types Sources
26973856 PubMed citation Europe PMC
27278257 PubMed citation Europe PMC
28675010 PubMed citation Europe PMC
28925507 PubMed citation Europe PMC
29228694 PubMed citation Europe PMC
30365505 PubMed citation Europe PMC
31572509 PubMed citation Europe PMC
31651209 PubMed citation Europe PMC
31720078 PubMed citation Europe PMC
32222493 PubMed citation Europe PMC
Last Modified
17 March 2021