CHEBI:194402 - satavaptan

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ChEBI Name satavaptan
ChEBI ID CHEBI:194402
Definition A vasopressin V2 receptor antagonist that has been shown to improve hyponatremia in patients with cirrhosis, congestive heart failure, and syndrome of inappropriate antidiuresis.
Stars This entity has been manually annotated by a third party.
Submitter Stan Laulederkind
Supplier Information
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Formula C33H45N3O8S
Net Charge 0
Average Mass 643.800
Monoisotopic Mass 643.29274
InChI InChI=1S/C33H45N3O8S/c1-6-43-25-8-9-27-26(22-25)33(13-11-24(12-14-33)44-20-17-35-15-18-42-19-16-35)31(38)36(27)45(39,40)29-10-7-23(21-28(29)41-5)30(37)34-32(2,3)4/h7-10,21-22,24H,6,11-20H2,1-5H3,(H,34,37)/t24-,33+
InChIKey QKXJWFOKVQWEDZ-VCCCEUOBSA-N
SMILES CCOC1=CC=C2N(C(=O)[C@@]3(CC[C@@H](CC3)OCCN3CCOCC3)C2=C1)S(=O)(=O)C1=C(OC)C=C(C=C1)C(=O)NC(C)(C)C
Roles Classification
Biological Role(s): vasopressin receptor antagonist
Any drug which blocks vasopressin receptors.
Application(s): vasopressin receptor antagonist
Any drug which blocks vasopressin receptors.
aquaretic
A class of diuretics which promote aquaresis (the excretion of water without electrolyte loss).
View more via ChEBI Ontology
ChEBI Ontology
Outgoing satavaptan (CHEBI:194402) has role aquaretic (CHEBI:194423)
satavaptan (CHEBI:194402) has role vasopressin receptor antagonist (CHEBI:59680)
satavaptan (CHEBI:194402) is a aromatic ether (CHEBI:35618)
satavaptan (CHEBI:194402) is a benzamides (CHEBI:22702)
satavaptan (CHEBI:194402) is a monomethoxybenzene (CHEBI:25235)
satavaptan (CHEBI:194402) is a morpholines (CHEBI:38785)
satavaptan (CHEBI:194402) is a oxaspiro compound (CHEBI:37948)
satavaptan (CHEBI:194402) is a secondary carboxamide (CHEBI:140325)
satavaptan (CHEBI:194402) is a sulfonamide (CHEBI:35358)
IUPAC Name
N-tert-butyl-4-[5'-ethoxy-4-(2-morpholin-4-ylethoxy)-2'-oxospiro[cyclohexane-1,3'-indole]-1'-yl]sulfonyl-3-methoxybenzamide
INNs Sources
satavaptán WHO MedNet
satavaptan WHO MedNet
satavaptan WHO MedNet
satavaptanum WHO MedNet
Synonyms Sources
SR 121463 ChEBI
SR-121463 SUBMITTER
SR121463 SUBMITTER
Brand Name Source
Aquilda
Note: (2023-02-20) Drug now withdrawn from the market by Sanofi-Aventis.
 ChEBI
Manual Xrefs Databases
DB14923 DrugBank
HMDB0257503 HMDB
Satavaptan Wikipedia
View more database links
Registry Number Type Source
185913-78-4 CAS Registry Number DrugBank
Citations Waiting for Citations Types Sources
10991964 PubMed citation Europe PMC
11890358 PubMed citation Europe PMC
24259510 PubMed citation SUBMITTER
35972345 PubMed citation SUBMITTER
8981918 PubMed citation Europe PMC
Last Modified
20 February 2023