CHEBI:149669 - apelin-12

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ChEBI Name apelin-12 ChEBI ID CHEBI:149669 Definition A 12 amino acid oligopeptide fragment of apelin-13 lacking the terminal L-phenylalanine residue. Stars This entity has been manually annotated by the ChEBI Team. Supplier Information Download Molfile XML SDF Find compounds which contain this structure Find compounds which resemble this structure Take structure to the Advanced Search Formula C60H102N22O15S Net Charge 0 Average Mass 1403.680 Monoisotopic Mass 1402.76157 InChI InChI=1S/C60H102N22O15S/c1-33(2)27-40(77-50(88)37(12-6-21-69-59(64)65)74-55(93)44-15-9-24-81(44)56(94)38(13-7-22-70-60(66)67)75-48(86)35(62)17-18-46(63)84)51(89)79-42(31-83)53(91)78-41(28-34-29-68-32-72-34)52(90)73-36(11-4-5-20-61)49(87)71-30-47(85)80-23-8-14-43(80)54(92)76-39(19-26-98-3)57(95)82-25-10-16-45(82)58(96)97/h29,32-33,35-45,83H,4-28,30-31,61-62H2,1-3H3,(H2,63,84)(H,68,72)(H,71,87)(H,73,90)(H,74,93)(H,75,86)(H,76,92)(H,77,88)(H,78,91)(H,79,89)(H,96,97)(H4,64,65,69)(H4,66,67,70)/t35-,36-,37-,38-,39-,40-,41-,42-,43-,44-,45-/m0/s1 InChIKey QZNKGTRFBWGADN-SLUWFFAESA-N SMILES OC(=O)[C@H]1N(CCC1)C([C@H](CCSC)NC(=O)[C@H]2N(CCC2)C(=O)CNC([C@H](CCCCN)NC([C@H](CC3=CN=CN3)NC([C@H](CO)NC([C@H](CC(C)C)NC([C@H](CCCNC(=N)N)NC(=O)[C@H]4N(CCC4)C([C@H](CCCNC(=N)N)NC([C@H](CCC(=O)N)N)=O)=O)=O)=O)=O)=O)=O)=O Metabolite of Species Details Homo sapiens (NCBI:txid9606) Found in blood serum (BTO:0000133). See: PubMed Roles Classification Chemical Role(s): Bronsted base A molecular entity capable of accepting a hydron from a donor (Bronsted acid). (via organic amino compound ) Biological Role(s): human metabolite Any mammalian metabolite produced during a metabolic reaction in humans (Homo sapiens). human blood serum metabolite Any metabolite (endogenous or exogenous) found in human blood serum samples. Application(s): neuroprotective agent Any compound that can be used for the treatment of neurodegenerative disorders. biomarker A substance used as an indicator of a biological state. View more via ChEBI Ontology ChEBI Ontology Outgoing apelin-12 (CHEBI:149669) has role biomarker (CHEBI:59163) apelin-12 (CHEBI:149669) has role human blood serum metabolite (CHEBI:85234) apelin-12 (CHEBI:149669) has role human metabolite (CHEBI:77746) apelin-12 (CHEBI:149669) has role neuroprotective agent (CHEBI:63726) apelin-12 (CHEBI:149669) is a oligopeptide (CHEBI:25676) apelin-12 (CHEBI:149669) is conjugate base of apelin-12(3+) (CHEBI:147396) Incoming apelin-12(3+) (CHEBI:147396) is conjugate acid of apelin-12 (CHEBI:149669) IUPAC Name L-glutaminyl-L-arginyl-L-prolyl-L-arginyl-L-leucyl-L-seryl-L-histidyl-L-lysylglycyl-L-prolyl-L-methionyl-L-proline Synonyms Sources apelin (1-12) HMDB apelin 12 ChEBI apelin-12 (human) ChEBI apelin-12 peptide ChEBI apelin-13 (1-12) ChEBI Gln-Arg-Pro-Arg-Leu-Ser-His-Lys-Gly-Pro-Met-Pro ChEBI H-Gln-Arg-Pro-Arg-Leu-Ser-His-Lys-Gly-Pro-Met-Pro-OH ChEBI L-Gln-L-Arg-L-Pro-L-Arg-L-Leu-L-Ser-L-His-L-Lys-L-Gly-L-Pro-L-Met-L-Pro ChEBI Q-R-P-R-L-S-H-K-G-P-M-P ChEBI QRPRLSHKGPMP ChEBI Manual Xref Database HMDB0060264 HMDB View more database links Citations Types Sources 11815627 PubMed citation Europe PMC 15486224 PubMed citation Europe PMC 26625520 PubMed citation Europe PMC 27770057 PubMed citation Europe PMC 28710384 PubMed citation Europe PMC 28728608 PubMed citation Europe PMC 29150476 PubMed citation Europe PMC 29949164 PubMed citation Europe PMC 30278567 PubMed citation Europe PMC 30696454 PubMed citation Europe PMC 31321006 PubMed citation Europe PMC 32099583 PubMed citation Europe PMC Last Modified 07 May 2020