CHEBI:177372 - naxagolide

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ChEBI Name naxagolide ChEBI ID CHEBI:177372 Definition An organic heterotricyclic compound that is (4aR,10bR)-3,4,4a,5,6,10b-hexahydro-2H-naphtho[1,2-b][1,4]oxazine substituted by propyl and hydroxy groups at positions 4 and 9, respectively. It is a potent dopamine D2-receptor agonist and its hydrochloride salt was under clinical development by Merck & Co as a potential antiparkinsonian agent (now discontinued). Stars This entity has been manually annotated by the ChEBI Team. Submitter Stan Laulederkind Supplier Information Download Molfile XML SDF Find compounds which contain this structure Find compounds which resemble this structure Take structure to the Advanced Search Formula C15H21NO2 Net Charge 0 Average Mass 247.338 Monoisotopic Mass 247.15723 InChI InChI=1S/C15H21NO2/c1-2-7-16-8-9-18-15-13-10-12(17)5-3-11(13)4-6-14(15)16/h3,5,10,14-15,17H,2,4,6-9H2,1H3/t14-,15-/m1/s1 InChIKey JCSREICEMHWFAY-HUUCEWRRSA-N SMILES [H][C@@]12CCC3=C(C=C(O)C=C3)[C@@]1([H])OCCN2CCC Roles Classification Chemical Role(s): Bronsted base A molecular entity capable of accepting a hydron from a donor (Bronsted acid). (via organic amino compound ) Biological Role(s): dopamine agonist A drug that binds to and activates dopamine receptors. Application(s): antiparkinson drug A drug used in the treatment of Parkinson's disease. dopamine agonist A drug that binds to and activates dopamine receptors. anticonvulsant A drug used to prevent seizures or reduce their severity. View more via ChEBI Ontology ChEBI Ontology Outgoing naxagolide (CHEBI:177372) has role anticonvulsant (CHEBI:35623) naxagolide (CHEBI:177372) has role antiparkinson drug (CHEBI:48407) naxagolide (CHEBI:177372) has role dopamine agonist (CHEBI:51065) naxagolide (CHEBI:177372) is a organic heterotricyclic compound (CHEBI:26979) naxagolide (CHEBI:177372) is a phenols (CHEBI:33853) naxagolide (CHEBI:177372) is a tertiary amino compound (CHEBI:50996) naxagolide (CHEBI:177372) is conjugate base of naxagolide(1+) (CHEBI:177380) Incoming naxagolide(1+) (CHEBI:177380) is conjugate acid of naxagolide (CHEBI:177372) IUPAC Name (4aR,10bR)-4-propyl-3,4,4a,5,6,10b-hexahydro-2H-naphtho[1,2-b][1,4]oxazin-9-ol INNs Sources naxagolida WHO MedNet naxagolide WHO MedNet naxagolide WHO MedNet naxagolidum WHO MedNet Synonyms Sources (+)-4-propyl-9-hydroxynaphthoxazine ChemIDplus (+)-PHNO ChemIDplus (4aR-trans)-3,4,4a,5,6,10b-hexahydro-4-propyl-2H-naphth[1,2-b]-1,4-oxazin-9-ol ChemIDplus dopazinol ChemIDplus nazagolide ChemIDplus PHNO ChEBI Manual Xref Database 51863 ChemSpider View more database links Registry Number Type Source 88058-88-2 CAS Registry Number ChemIDplus Citations Types Sources 10956195 PubMed citation Europe PMC 11105937 PubMed citation Europe PMC 15646539 PubMed citation Europe PMC 15943487 PubMed citation Europe PMC 1681090 PubMed citation Europe PMC 1840645 PubMed citation Europe PMC 19635669 PubMed citation Europe PMC 2140595 PubMed citation Europe PMC 24325578 PubMed citation Europe PMC 2904649 PubMed citation SUBMITTER 3758188 PubMed citation Europe PMC 6433000 PubMed citation Europe PMC 8078498 PubMed citation SUBMITTER 8301582 PubMed citation Europe PMC Last Modified 13 August 2021