DMH4 (CHEBI:229963)

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ChEBI Name	DMH4

ChEBI ID	CHEBI:229963

Definition	A pyrazolopyrimidine that is pyrazolo[1,5-a]pyrimidine substituted by phenyl and 4-[2-(morpholin-4-yl)ethoxy]phenyl groups at positions 3 and 6, respectively. It is an inhibitor of VEGFR-2 (IC₅₀ = 0.16 μM).

Stars	This entity has been manually annotated by the ChEBI Team.

Submitter	Doug Howe

Supplier Information

Download	Molfile XML SDF

Formula

C24H24N4O2

Net Charge

Average Mass

400.482

Monoisotopic Mass

400.18993

InChI

InChI=1S/C24H24N4O2/c1-2-4-20(5-3-1)23-17-26-28-18-21(16-25-24(23)28)19-6-8-22(9-7-19)30-15-12-27-10-13-29-14-11-27/h1-9,16-18H,10-15H2

InChIKey

SKZQZGSPYYHTQG-UHFFFAOYSA-N

SMILES

C(CN1CCOCC1)OC1=CC=C(C=C1)C1=CN2N=CC(=C2N=C1)C1=CC=CC=C1

Roles Classification
Chemical Role(s):	Bronsted base A molecular entity capable of accepting a hydron from a donor (Bronsted acid). (via organic amino compound )

Biological Role(s):	apoptosis inducer Any substance that induces the process of apoptosis (programmed cell death) in multi-celled organisms. EC 2.7.10.1 (receptor protein-tyrosine kinase) inhibitor An EC 2.7.10.* (protein-tyrosine kinase) inhibitor that interferes with the action of receptor protein-tyrosine kinase (EC 2.7.10.1). vascular endothelial growth factor receptor antagonist An antagonist at the vascular endothelial growth factor receptor.

Application(s):	angiogenesis inhibitor An agent and endogenous substances that antagonize or inhibit the development of new blood vessels. antineoplastic agent A substance that inhibits or prevents the proliferation of neoplasms.

ChEBI Ontology
Outgoing	DMH4 (CHEBI:229963) has role angiogenesis inhibitor (CHEBI:48422) DMH4 (CHEBI:229963) has role antineoplastic agent (CHEBI:35610) DMH4 (CHEBI:229963) has role apoptosis inducer (CHEBI:68495) DMH4 (CHEBI:229963) has role EC 2.7.10.1 (receptor protein-tyrosine kinase) inhibitor (CHEBI:62434) DMH4 (CHEBI:229963) has role vascular endothelial growth factor receptor antagonist (CHEBI:65207) DMH4 (CHEBI:229963) is a aromatic ether (CHEBI:35618) DMH4 (CHEBI:229963) is a benzenes (CHEBI:22712) DMH4 (CHEBI:229963) is a morpholines (CHEBI:38785) DMH4 (CHEBI:229963) is a pyrazolopyrimidine (CHEBI:38669) DMH4 (CHEBI:229963) is a tertiary amino compound (CHEBI:50996)

IUPAC Name

6-{4-[2-(morpholin-4-yl)ethoxy]phenyl}-3-phenylpyrazolo[1,5-a]pyrimidine

Synonyms	Sources
3-phenyl-6-[4-(2-morpholinoethoxy)phenyl]pyrazolo[1,5-a]pyrimidine	ChEBI
6-[4-[2-(4-morpholinyl)ethoxy]phenyl]-3-phenyl-pyrazolo[1,5-a]pyrimidine	ChEBI
DMH 4	ChEBI

Registry Number	Type	Source
515880-75-8	CAS Registry Number	ChEBI

Last Modified

12 April 2024