savolitinib (CHEBI:231369)

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ChEBI Name	savolitinib

ChEBI ID	CHEBI:231369

Definition	A member of the class of triazolopyrazines that is 1H-[1,2,3]triazolo[4,5-b]pyrazine substituted by (1S)-1-(imidazo[1,2-a]pyridin-6-yl)ethyl and 1-methyl-1H-pyrazol-4-yl groups at positions 1 and 6, respectively. It is a highly selective MET tyrosine kinase inhibitor that is approved in China for advanced NSCLC with MET exon 14 skipping mutations.

Stars	This entity has been manually annotated by the ChEBI Team.

Submitter	Delphine Zhou

Supplier Information

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Formula

C17H15N9

Net Charge

Average Mass

345.370

Monoisotopic Mass

345.14504

InChI

InChI=1S/C17H15N9/c1-11(12-3-4-15-18-5-6-25(15)10-12)26-17-16(22-23-26)19-8-14(21-17)13-7-20-24(2)9-13/h3-11H,1-2H3/t11-/m0/s1

InChIKey

XYDNMOZJKOGZLS-NSHDSACASA-N

SMILES

C[C@H](N1N=NC2=NC=C(N=C12)C1=CN(C)N=C1)C1=CN2C=CN=C2C=C1

Roles Classification
Biological Role(s):	c-Met tyrosine kinase inhibitor An EC 2.7.10.1 (receptor protein-tyrosine kinase) inhibitor that interferes with the action of c-Met tyrosine kinase.

Application(s):	antineoplastic agent A substance that inhibits or prevents the proliferation of neoplasms.

ChEBI Ontology
Outgoing	savolitinib (CHEBI:231369) has role antineoplastic agent (CHEBI:35610) savolitinib (CHEBI:231369) has role c-Met tyrosine kinase inhibitor (CHEBI:90199) savolitinib (CHEBI:231369) is a imidazopyridine (CHEBI:46908) savolitinib (CHEBI:231369) is a pyrazoles (CHEBI:26410) savolitinib (CHEBI:231369) is a triazolopyrazine (CHEBI:48277)

IUPAC Name

1-[(1S)-1-(imidazo[1,2-a]pyridin-6-yl)ethyl]-6-(1-methyl-1H-pyrazol-4-yl)-1H-[1,2,3]triazolo[4,5-b]pyrazine

Synonyms	Sources
1-[(1S)-1-imidazo[1,2-a]pyridin-6-ylethyl]-6-(1-methyl-1H-pyrazol-4-yl)-1H-1,2,3-triazolo[4,5-b]pyrazine	ChEBI
3-[(1S)-1-imidazo[1,2-a]pyridin-6-ylethyl]-5-(1-methylpyrazol-4-yl)triazolo[4,5-b]pyrazine	ChEBI
AZD 6094	ChEBI
AZD-6094	SUBMITTER
AZD6094	DrugBank
HM 5016504	ChEBI
HM-5016504	ChEBI
HMPL 504	ChEBI
HMPL-504	DrugBank
volitinib	DrugBank

Brand Name	Source
Orpathys	ChEBI

Registry Number	Type	Source
1313725-88-0	CAS Registry Number	KEGG DRUG

Last Modified

09 May 2024