tiratricol (CHEBI:40021)

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ChEBI Name	tiratricol

ChEBI ID	CHEBI:40021

Definition	A monocarboxylic acid that is (4-hydroxy-3,5-diiodophenyl)acetic acid in which the phenolic hydroxy group has been replaced by a 4-hydroxy-3-iodophenoxy group. It is a thyroid hormone analogue that has been used in the treatment of thyroid hormone resistance syndrome.

Stars	This entity has been manually annotated by the ChEBI Team.

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Formula

C14H9I3O4

Net Charge

Average Mass

621.935

Monoisotopic Mass

621.76349

InChI

InChI=1S/C14H9I3O4/c15-9-6-8(1-2-12(9)18)21-14-10(16)3-7(4-11(14)17)5-13(19)20/h1-4,6,18H,5H2,(H,19,20)

InChIKey

UOWZUVNAGUAEQC-UHFFFAOYSA-N

SMILES

OC(=O)CC1=CC(I)=C(OC2=CC(I)=C(O)C=C2)C(I)=C1

Roles Classification
Chemical Role(s):	Bronsted acid A molecular entity capable of donating a hydron to an acceptor (Bronsted base). (via oxoacid )

Biological Role(s):	thyroid hormone Any hormone produced by the thyroid gland antiviral agent A substance that destroys or inhibits replication of viruses. EC 1.3.5.2 [dihydroorotate dehydrogenase (quinone)] inhibitor An EC 1.3.5.* (oxidoreductase acting on CH-CH of donor with a quinone or related compound as acceptor) inhibitor that interferes with the action of dihydroorotate dehydrogenase (quinone), EC 1.3.5.2. human metabolite Any mammalian metabolite produced during a metabolic reaction in humans (Homo sapiens). anti-obesity agent Any substance which is used to reduce or control weight.

Application(s):	nutraceutical A product in capsule, tablet or liquid form that provide essential nutrients, such as a vitamin, an essential mineral, a protein, an herb, or similar nutritional substance.

ChEBI Ontology
Outgoing	tiratricol (CHEBI:40021) has role anti-obesity agent (CHEBI:74518) tiratricol (CHEBI:40021) has role antiviral agent (CHEBI:22587) tiratricol (CHEBI:40021) has role EC 1.3.5.2 [dihydroorotate dehydrogenase (quinone)] inhibitor (CHEBI:77103) tiratricol (CHEBI:40021) has role human metabolite (CHEBI:77746) tiratricol (CHEBI:40021) has role nutraceutical (CHEBI:50733) tiratricol (CHEBI:40021) has role thyroid hormone (CHEBI:60311) tiratricol (CHEBI:40021) is a aromatic ether (CHEBI:35618) tiratricol (CHEBI:40021) is a monocarboxylic acid (CHEBI:25384) tiratricol (CHEBI:40021) is a organoiodine compound (CHEBI:37142) tiratricol (CHEBI:40021) is a phenols (CHEBI:33853)

IUPAC Name

[4-(4-hydroxy-3-iodophenoxy)-3,5-diiodophenyl]acetic acid

Synonyms	Sources
2-[4-(4-hydroxy-3-iodophenoxy)-3,5-diiodophenyl]acetic acid	ChEBI
3,3',5-triiodothyroacetic acid	ChEBI
4-(4-hydroxy-3-iodophenoxy)-3,5-diiodobenzeneacetic acid	ChEBI
[(4-hydroxy-3-iodo-4-phenoxy)-3,5-diiodophenyl]acetic acid	ChEBI
T3A	ChEBI
TRIAC	ChEBI
triiodothyroacetic acid	ChEBI

Registry Number	Type	Source
51-24-1	CAS Registry Number	DrugBank

Last Modified

12 January 2024