CHEBI:72761 - tryprostatin A

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ChEBI Name tryprostatin A
ChEBI ID CHEBI:72761
Definition A cyclic dipeptide that is brevianamide F (cyclo-L-Trp-L-Pro) substituted at positions 2 and 6 on the indole ring by prenyl and methoxy groups respectively.
Stars This entity has been manually annotated by the ChEBI Team.
Submitter KAX
Supplier Information
Download Molfile XML SDF
Formula C22H27N3O3
Net Charge 0
Average Mass 381.46810
Monoisotopic Mass 381.20524
InChI InChI=1S/C22H27N3O3/c1-13(2)6-9-17-16(15-8-7-14(28-3)11-18(15)23-17)12-19-22(27)25-10-4-5-20(25)21(26)24-19/h6-8,11,19-20,23H,4-5,9-10,12H2,1-3H3,(H,24,26)/t19-,20-/m0/s1
InChIKey XNRPVPHNDQHWLJ-PMACEKPBSA-N
SMILES [H][C@@]12CCCN1C(=O)[C@H](Cc1c(CC=C(C)C)[nH]c3cc(OC)ccc13)NC2=O
Roles Classification
Chemical Role(s): Bronsted base
A molecular entity capable of accepting a hydron from a donor (Bronsted acid).
(via organic amino compound )
Biological Role(s): breast cancer resistance protein inhibitor
Any inhibitor of breast cancer resistance protein (ABCG2).
metabolite
Any intermediate or product resulting from metabolism. The term 'metabolite' subsumes the classes commonly known as primary and secondary metabolites.
(via alkaloid )
View more via ChEBI Ontology
ChEBI Ontology
Outgoing tryprostatin A (CHEBI:72761) has functional parent brevianamide F (CHEBI:64530)
tryprostatin A (CHEBI:72761) has role breast cancer resistance protein inhibitor (CHEBI:72771)
tryprostatin A (CHEBI:72761) is a aromatic ether (CHEBI:35618)
tryprostatin A (CHEBI:72761) is a dipeptide (CHEBI:46761)
tryprostatin A (CHEBI:72761) is a indole alkaloid (CHEBI:38958)
tryprostatin A (CHEBI:72761) is a indoles (CHEBI:24828)
tryprostatin A (CHEBI:72761) is a pyrrolopyrazine (CHEBI:48337)
IUPAC Name
(3S,8aS)-3-{[6-methoxy-2-(3-methylbut-2-en-1-yl)-1H-indol-3-yl]methyl}hexahydropyrrolo[1,2-a]pyrazine-1,4-dione
Synonym Source
tryprostatin A UniProt
Manual Xrefs Databases
EP1464336 Patent
WO2004087162 Patent
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Citations Waiting for Citations Types Sources
11931609 PubMed citation Europe PMC
14566821 PubMed citation Europe PMC
18321710 PubMed citation Europe PMC
19226505 PubMed citation SUBMITTER
9677311 PubMed citation Europe PMC
Last Modified
02 April 2013