fezolinetant (CHEBI:229236)

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ChEBI Name	fezolinetant

ChEBI ID	CHEBI:229236

Definition	A triazolopyrazine that is 5,6,7,8-tetrahydro[1,2,4]triazolo[4,3-a]pyrazine substituted by 3-methyl-1,2,4-thiadiazol-5-yl, 4-fluorobenzoyl and methyl groups at positions 3, 7, and 8R, respectively. It is a prescription medicine used to reduce moderate to severe vasomotor symptoms due to menopause.

Stars	This entity has been manually annotated by the ChEBI Team.

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Formula

C16H15FN6OS

Net Charge

Average Mass

358.400

Monoisotopic Mass

358.10121

InChI

InChI=1S/C16H15FN6OS/c1-9-13-19-20-14(15-18-10(2)21-25-15)23(13)8-7-22(9)16(24)11-3-5-12(17)6-4-11/h3-6,9H,7-8H2,1-2H3/t9-/m1/s1

InChIKey

PPSNFPASKFYPMN-SECBINFHSA-N

SMILES

C[C@H]1N(CCN2C1=NN=C2C1=NC(C)=NS1)C(=O)C1=CC=C(F)C=C1

Roles Classification
Biological Role(s):	neurokinin-3 receptor antagonist An antagonist at the neurokinin-3 receptor.

ChEBI Ontology
Outgoing	fezolinetant (CHEBI:229236) has role neurokinin-3 receptor antagonist (CHEBI:140482) fezolinetant (CHEBI:229236) is a benzamides (CHEBI:22702) fezolinetant (CHEBI:229236) is a monofluorobenzenes (CHEBI:83575) fezolinetant (CHEBI:229236) is a tertiary carboxamide (CHEBI:140326) fezolinetant (CHEBI:229236) is a thiadiazoles (CHEBI:38099) fezolinetant (CHEBI:229236) is a triazolopyrazine (CHEBI:48277)

IUPAC Name

(4-fluorophenyl)[(8R)-8-methyl-3-(3-methyl-1,2,4-thiadiazol-5-yl)-5,6-dihydro[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl]methanone

Brand Name	Source
Veozah	DrugBank

Registry Number	Type	Source
1629229-37-3	CAS Registry Number	KEGG DRUG

Last Modified

16 April 2024