SU4312 (CHEBI:92369)

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ChEBI Name	SU4312

ChEBI ID	CHEBI:92369

Definition	A member of the class of oxindoles that is 3-methyleneoxindole in which one of the hydrogens of the methylene group has been replaced by a p-(dimethylamino)phenyl group. SU 4312 is a vascular endothelial growth factor (VEGF) receptor protein tyrosine kinase 1/2 and platelet derived growth factor (PDGF) receptor inhibitor. It also inhibits the neuronal nitric oxide synthase (NOS) and exhibits neuroprotection against NO-mediated neurotoxicity.

Stars	This entity has been manually annotated by the ChEBI Team.

Supplier Information

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Formula

C17H16N2O

Net Charge

Average Mass

264.322

Monoisotopic Mass

264.12626

InChI

InChI=1S/C17H16N2O/c1-19(2)13-9-7-12(8-10-13)11-15-14-5-3-4-6-16(14)18-17(15)20/h3-11H,1-2H3,(H,18,20)

InChIKey

UAKWLVYMKBWHMX-UHFFFAOYSA-N

SMILES

N1C(C(C2=C1C=CC=C2)=CC=3C=CC(=CC3)N(C)C)=O

Roles Classification
Chemical Role(s):	Bronsted base A molecular entity capable of accepting a hydron from a donor (Bronsted acid). (via organic amino compound )

Biological Role(s):	vascular endothelial growth factor receptor antagonist An antagonist at the vascular endothelial growth factor receptor.

Application(s):	angiogenesis inhibitor An agent and endogenous substances that antagonize or inhibit the development of new blood vessels. antineoplastic agent A substance that inhibits or prevents the proliferation of neoplasms. geroprotector Any compound that supports healthy aging, slows the biological aging process, or extends lifespan. neuroprotective agent Any compound that can be used for the treatment of neurodegenerative disorders.

ChEBI Ontology
Outgoing	SU4312 (CHEBI:92369) has role angiogenesis inhibitor (CHEBI:48422) SU4312 (CHEBI:92369) has role antineoplastic agent (CHEBI:35610) SU4312 (CHEBI:92369) has role geroprotector (CHEBI:176497) SU4312 (CHEBI:92369) has role neuroprotective agent (CHEBI:63726) SU4312 (CHEBI:92369) has role vascular endothelial growth factor receptor antagonist (CHEBI:65207) SU4312 (CHEBI:92369) is a oxindoles (CHEBI:38459) SU4312 (CHEBI:92369) is a substituted aniline (CHEBI:48975) SU4312 (CHEBI:92369) is a tertiary amino compound (CHEBI:50996)

IUPAC Name

3-[4-(dimethylamino)benzylidene]-1,3-dihydro-2H-indol-2-one

Synonyms	Sources
3-(4-dimethylamino-benzylidenyl)-2-indolinone	ChemIDplus
3-[[4-(dimethylamino)phenyl]methylidene]-1H-indol-2-one	LINCS
DMBI	ChemIDplus
SU 4312	ChemIDplus
SU-4312	ChEBI

Last Modified

28 October 2021