CHEBI:228304 - vamorolone

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ChEBI Name vamorolone
ChEBI ID CHEBI:228304
Definition A 3-oxo-Δ1,Δ4-steroid that is pregna-1,4,9(11)-trien-17-ol substituted by oxo, oxo, and hydroxy groups at positions 3, 20, and 21, respectively. It is approved by the FDA for the treatment of patients with Duchenne muscular dystrophy aged 2 years and older.
Stars This entity has been manually annotated by the ChEBI Team.
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Formula C22H28O4
Net Charge 0
Average Mass 356.462
Monoisotopic Mass 356.19876
InChI InChI=1S/C22H28O4/c1-13-10-18-16-5-4-14-11-15(24)6-8-20(14,2)17(16)7-9-21(18,3)22(13,26)19(25)12-23/h6-8,11,13,16,18,23,26H,4-5,9-10,12H2,1-3H3/t13-,16-,18+,20+,21+,22+/m1/s1
InChIKey ZYTXTXAMMDTYDQ-DGEXFFLYSA-N
SMILES [H][C@@]12C[C@@H](C)[C@](O)(C(=O)CO)[C@@]1(C)CC=C1[C@@]2([H])CCC2=CC(=O)C=C[C@]12C
Roles Classification
Biological Role(s): immunosuppressive agent
An agent that suppresses immune function by one of several mechanisms of action. Classical cytotoxic immunosuppressants act by inhibiting DNA synthesis. Others may act through activation of T-cells or by inhibiting the activation of helper cells. In addition, an immunosuppressive agent is a role played by a compound which is exhibited by a capability to diminish the extent and/or voracity of an immune response.
glucocorticoid receptor agonist
An agonist that selectively binds to and activates a glucocorticoid receptor.
Application(s): anti-inflammatory drug
A substance that reduces or suppresses inflammation.
immunosuppressive agent
An agent that suppresses immune function by one of several mechanisms of action. Classical cytotoxic immunosuppressants act by inhibiting DNA synthesis. Others may act through activation of T-cells or by inhibiting the activation of helper cells. In addition, an immunosuppressive agent is a role played by a compound which is exhibited by a capability to diminish the extent and/or voracity of an immune response.
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ChEBI Ontology
Outgoing vamorolone (CHEBI:228304) has role anti-inflammatory drug (CHEBI:35472)
vamorolone (CHEBI:228304) has role glucocorticoid receptor agonist (CHEBI:63562)
vamorolone (CHEBI:228304) has role immunosuppressive agent (CHEBI:35705)
vamorolone (CHEBI:228304) is a 17α-hydroxy steroid (CHEBI:35342)
vamorolone (CHEBI:228304) is a 20-oxo steroid (CHEBI:36885)
vamorolone (CHEBI:228304) is a 21-hydroxy steroid (CHEBI:35344)
vamorolone (CHEBI:228304) is a 3-oxo-Δ1,Δ4-steroid (CHEBI:77166)
vamorolone (CHEBI:228304) is a corticosteroid (CHEBI:50858)
vamorolone (CHEBI:228304) is a primary α-hydroxy ketone (CHEBI:139590)
vamorolone (CHEBI:228304) is a tertiary α-hydroxy ketone (CHEBI:139592)
IUPAC Name
17,21-dihydroxy-16α-methylpregna-1,4,9(11)-triene-3,20-dione
INNs Sources
vamorolona WHO MedNet
vamorolone WHO MedNet
vamorolone WHO MedNet
vamorolonum WHO MedNet
Synonyms Sources
(16α)-17,21-dihydroxy-16-methylpregna-1,4,9(11)-triene-3,20-dione ChEBI
17α,21-dihydroxy-16α-methylpregna-1,4,9(11)-triene-3,20-dione ChEBI
VBP 15 ChEBI
VBP-15 ChEBI
VBP15 DrugBank
Brand Name Source
Agamree KEGG DRUG
Manual Xrefs Databases
D11000 KEGG DRUG
DB15114 DrugBank
Vamorolone Wikipedia
View more database links
Registry Number Type Source
13209-41-1 CAS Registry Number KEGG DRUG
Citations Waiting for Citations Types Sources
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Last Modified
21 February 2024