CHEBI:6932 - midazolam hydrochloride

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ChEBI Name midazolam hydrochloride
ChEBI ID CHEBI:6932
Definition The hydrochloride salt of midazolam.
Stars This entity has been manually annotated by the ChEBI Team.
Supplier Information
Download Molfile XML SDF
Formulae C18H13ClFN3.HCl
C18H14Cl2FN3
Net Charge 0
Average Mass 362.229
Monoisotopic Mass 361.05488
InChI InChI=1S/C18H13ClFN3.ClH/c1-11-21-9-13-10-22-18(14-4-2-3-5-16(14)20)15-8-12(19)6-7-17(15)23(11)13;/h2-9H,10H2,1H3;1H
InChIKey PLYSCVSCYOQVRP-UHFFFAOYSA-N
SMILES Cl.C1(=NCC=2N(C=3C1=CC(=CC3)Cl)C(=NC2)C)C=4C=CC=CC4F
Roles Classification
Biological Role(s): apoptosis inducer
Any substance that induces the process of apoptosis (programmed cell death) in multi-celled organisms.
GABAA receptor agonist
A GABA receptor agonist specific for GABAA receptors, ligand-gated ion channels (also known as ionotropic receptors).
GABA modulator
A substance that does not act as agonist or antagonist but does affect the gamma-aminobutyric acid receptor-ionophore complex. GABA-A receptors appear to have at least three allosteric sites at which modulators act: a site at which benzodiazepines act by increasing the opening frequency of gamma-aminobutyric acid-activated chloride channels; a site at which barbiturates act to prolong the duration of channel opening; and a site at which some steroids may act.
(via benzodiazepine )
Application(s): anticonvulsant
A drug used to prevent seizures or reduce their severity.
antineoplastic agent
A substance that inhibits or prevents the proliferation of neoplasms.
anxiolytic drug
Anxiolytic drugs are agents that alleviate anxiety, tension, and anxiety disorders, promote sedation, and have a calming effect without affecting clarity of consciousness or neurologic conditions.
central nervous system depressant
A loosely defined group of drugs that tend to reduce the activity of the central nervous system.
GABAA receptor agonist
A GABA receptor agonist specific for GABAA receptors, ligand-gated ion channels (also known as ionotropic receptors).
general anaesthetic
Substance that produces loss of consciousness.
muscle relaxant
A drug used to produce muscle relaxation (excepting neuromuscular blocking agents). Its primary clinical and therapeutic use is the treatment of muscle spasm and immobility associated with strains, sprains, and injuries of the back and, to a lesser degree, injuries to the neck. Also used for the treatment of a variety of clinical conditions that have in common only the presence of skeletal muscle hyperactivity, for example, the muscle spasms that can occur in multiple sclerosis.
sedative
A central nervous system depressant used to induce drowsiness or sleep or to reduce psychological excitement or anxiety.
GABA modulator
A substance that does not act as agonist or antagonist but does affect the gamma-aminobutyric acid receptor-ionophore complex. GABA-A receptors appear to have at least three allosteric sites at which modulators act: a site at which benzodiazepines act by increasing the opening frequency of gamma-aminobutyric acid-activated chloride channels; a site at which barbiturates act to prolong the duration of channel opening; and a site at which some steroids may act.
(via benzodiazepine )
View more via ChEBI Ontology
ChEBI Ontology
Outgoing midazolam hydrochloride (CHEBI:6932) has part midazolam (CHEBI:6931)
midazolam hydrochloride (CHEBI:6932) has role anticonvulsant (CHEBI:35623)
midazolam hydrochloride (CHEBI:6932) has role antineoplastic agent (CHEBI:35610)
midazolam hydrochloride (CHEBI:6932) has role anxiolytic drug (CHEBI:35474)
midazolam hydrochloride (CHEBI:6932) has role apoptosis inducer (CHEBI:68495)
midazolam hydrochloride (CHEBI:6932) has role central nervous system depressant (CHEBI:35488)
midazolam hydrochloride (CHEBI:6932) has role GABAA receptor agonist (CHEBI:91016)
midazolam hydrochloride (CHEBI:6932) has role general anaesthetic (CHEBI:38869)
midazolam hydrochloride (CHEBI:6932) has role muscle relaxant (CHEBI:51371)
midazolam hydrochloride (CHEBI:6932) has role sedative (CHEBI:35717)
midazolam hydrochloride (CHEBI:6932) is a hydrochloride (CHEBI:36807)
midazolam hydrochloride (CHEBI:6932) is a imidazobenzodiazepine (CHEBI:142118)
IUPAC Name
8-chloro-6-(2-fluorophenyl)-1-methyl-4H-imidazo[1,5-a][1,4]benzodiazepine hydrochloride
Synonyms Sources
midazolam HCl ChEBI
midazolam hydrochloride KEGG DRUG
Brand Names Sources
Buccolam ChEBI
Dormicum ChEBI
Hypnovel ChEBI
Versed KEGG DRUG
Manual Xrefs Databases
D00696 KEGG DRUG
DB00683 DrugBank
HMDB0014821 HMDB
View more database links
Registry Numbers Types Sources
59467-96-8 CAS Registry Number ChemIDplus
59467-96-8 CAS Registry Number DrugBank
6580691 Reaxys Registry Number Reaxys
Citations Waiting for Citations Types Sources
21817086 PubMed citation Europe PMC
28577272 PubMed citation Europe PMC
29287157 PubMed citation Europe PMC
Last Modified
06 September 2018