Services
Research
Training
Industry
About us
ChEBI
Examples:
iron*
,
InChI=1S/CH4O/c1-2/h2H,1H3
,
caffeine
Advanced
Home
Advanced Search
Browse
Documentation
Download
Tools
About ChEBI
Submit
Contact us
DiNA
Statistics
Entity of the Month
Periodic Table
Ontology
Train online
User Manual
Annotation Manual
Developer Manual
FAQ's
BiNChE
libChEBI
Web Services
ChEBI
> Main
CHEBI:69621 - trichothecin
Main
ChEBI Ontology
Automatic Xrefs
Reactions
Pathways
Models
ChEBI Name
trichothecin
ChEBI ID
CHEBI:69621
Definition
A trichothecene mycototoxin isolated from the endophytic fungus
Trichothecium sp.
and it exhibits anti-cancer properties.
Stars
This entity has been manually annotated by the ChEBI Team.
Secondary ChEBI IDs
CHEBI:9692
Supplier Information
Download
Molfile
XML
SDF
Find compounds which contain this structure
Find compounds which resemble this structure
Take structure to the Advanced Search
more structures >>
Molfile
Formula
C19H24O5
Net Charge
0
Average Mass
332.396
Monoisotopic Mass
332.16237
InChI
InChI=1S/C19H24O5/c1-
5-
6-
16(21)
24-
14-
8-
15-
19(10-
22-
19)
18(14,4)
17(3)
9-
12(20)
11(2)
7-
13(17)
23-
15/h5-
7,13-
15H,8-
10H2,1-
4H3/b6-
5-
/t13-
,14-
,15-
,17+,18-
,19+/m1/s1
InChIKey
LJWZOKOFCBPNAG-HULHSAFCSA-N
SMILES
[H][C@@]12C[C@@H](OC(=O)\C=C/C)[C@@](C)([C@]11CO1)[C@@]1(C)CC(=O)C(C)=C[C@@]1([H])O2
Metabolite of Species
Details
Trichothecium
sp.
MSX_51320
(NCBI:txid1094547)
Mycosynthetix fungal strain was isolated by Dr.Barry Katz from leaf litter See:
PubMed
Engleromyces goetzii
(NCBI:txid251718)
See:
PubMed
Holarrhena floribunda
(NCBI:txid2708850)
Found in stem
(BTO:0001300)
. See:
PubMed
Trichothecium roseum
(NCBI:txid47278)
See:
PubMed
Trichothecium roseum
(NCBI:txid47278)
of strain LZ93 See:
PubMed
Roles Classification
Biological Role
(s):
apoptosis inducer
Any substance that induces the process of apoptosis (programmed cell death) in multi-celled organisms.
mycotoxin
Poisonous substance produced by fungi.
(via
trichothecene
)
protein synthesis inhibitor
A compound, usually an anti-bacterial agent or a toxin, which inhibits the synthesis of a protein.
STAT3 inhibitor
An inhibitor of signal transducer and activator of transcription 3 (STAT3)
antifungal agent
An antimicrobial agent that destroys fungi by suppressing their ability to grow or reproduce.
Application
(s):
antineoplastic agent
A substance that inhibits or prevents the proliferation of neoplasms.
View more via ChEBI Ontology
ChEBI Ontology
Outgoing
trichothecin (
CHEBI:69621
)
has role
antifungal agent (
CHEBI:35718
)
trichothecin (
CHEBI:69621
)
has role
antineoplastic agent (
CHEBI:35610
)
trichothecin (
CHEBI:69621
)
has role
apoptosis inducer (
CHEBI:68495
)
trichothecin (
CHEBI:69621
)
has role
mycotoxin (
CHEBI:25442
)
trichothecin (
CHEBI:69621
)
has role
protein synthesis inhibitor (
CHEBI:48001
)
trichothecin (
CHEBI:69621
)
has role
STAT3 inhibitor (
CHEBI:87183
)
trichothecin (
CHEBI:69621
)
is a
trichothecene (
CHEBI:55517
)
IUPAC Name
8-oxo-12,13-epoxytrichothec-9-en-4β-yl (2
Z
)-but-2-enoate
Synonyms
Sources
(4β)-12,13-epoxy-4-[[(2
Z
)-1-oxo-2-butenyl]oxy]trichothec-9-en-8-one
ChEBI
trichothecin
KEGG COMPOUND
Manual Xrefs
Databases
10216230
ChemSpider
C00003196
KNApSAcK
C09742
KEGG COMPOUND
View more database links
Registry Numbers
Types
Sources
6379-69-7
CAS Registry Number
KEGG COMPOUND
6379-69-7
CAS Registry Number
ChemIDplus
Citations
Types
Sources
10650079
PubMed citation
Europe PMC
12757719
PubMed citation
Europe PMC
19938595
PubMed citation
Europe PMC
21221935
PubMed citation
Europe PMC
21978324
PubMed citation
Europe PMC
22118979
PubMed citation
Europe PMC
23606003
PubMed citation
Europe PMC
23936501
PubMed citation
Europe PMC
25633363
PubMed citation
Europe PMC
27245696
PubMed citation
Europe PMC
2763715
PubMed citation
Europe PMC
29152681
PubMed citation
Europe PMC
31291971
PubMed citation
Europe PMC
31678511
PubMed citation
Europe PMC
32422984
PubMed citation
Europe PMC
33791150
PubMed citation
Europe PMC
6993881
PubMed citation
Europe PMC
8055913
PubMed citation
Europe PMC
IND607358060
Agricola citation
Europe PMC
Last Modified
15 October 2021