CHEBI:150866 - GS-441524 monophosphate

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ChEBI Name GS-441524 monophosphate
ChEBI ID CHEBI:150866
Definition A C-nucleoside phosphate that is GS-441524 in which the 5'-hydroxy group has been replaced by a phosphate group. In cells, GS-441524 monophosphate gets converted into the pharmacologically active triphosphate form (GS-443902).
Stars This entity has been manually annotated by the ChEBI Team.
Submitter Margaret Duesbury
Supplier Information
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Formula C12H14N5O7P
Net Charge 0
Average Mass 371.246
Monoisotopic Mass 371.06308
InChI InChI=1S/C12H14N5O7P/c13-4-12(8-2-1-6-11(14)15-5-16-17(6)8)10(19)9(18)7(24-12)3-23-25(20,21)22/h1-2,5,7,9-10,18-19H,3H2,(H2,14,15,16)(H2,20,21,22)/t7-,9-,10-,12+/m1/s1
InChIKey ZBHOHJWLOOFLMW-LTGWCKQJSA-N
SMILES [C@]1(O[C@@H]([C@H]([C@H]1O)O)COP(O)(=O)O)(C#N)C=2N3N=CN=C(C3=CC2)N
Roles Classification
Chemical Role(s): Bronsted base
A molecular entity capable of accepting a hydron from a donor (Bronsted acid).
(via organic amino compound )
Biological Role(s): anticoronaviral agent
Any antiviral agent which inhibits the activity of coronaviruses.
antiviral drug
A substance used in the prophylaxis or therapy of virus diseases.
drug metabolite

Application(s): antiviral drug
A substance used in the prophylaxis or therapy of virus diseases.
View more via ChEBI Ontology
ChEBI Ontology
Outgoing GS-441524 monophosphate (CHEBI:150866) has functional parent GS-441524 (CHEBI:147281)
GS-441524 monophosphate (CHEBI:150866) has role anticoronaviral agent (CHEBI:149553)
GS-441524 monophosphate (CHEBI:150866) has role antiviral drug (CHEBI:36044)
GS-441524 monophosphate (CHEBI:150866) has role drug metabolite (CHEBI:49103)
GS-441524 monophosphate (CHEBI:150866) is a C-nucleoside phosphate (CHEBI:37040)
GS-441524 monophosphate (CHEBI:150866) is a aromatic amine (CHEBI:33860)
GS-441524 monophosphate (CHEBI:150866) is a nitrile (CHEBI:18379)
GS-441524 monophosphate (CHEBI:150866) is a pyrrolotriazine (CHEBI:88341)
IUPAC Name
[(2R,3S,4R,5R)-5-(4-aminopyrrolo[2,1-f][1,2,4]triazin-7-yl)-5-cyano-3,4-dihydroxytetrahydrofuran-2-yl]methyl dihydrogen phosphate
Synonyms Sources
GS-441524 monophosphate ChEBI
RDV-MP
Note: (2020-06-03) Used as an abbreviation in some journal articles.
 ChEBI
remdesivir monophosphate ChEBI
Manual Xref Database
F86 PDBeChem
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Citations Waiting for Citations Types Sources
32358203 PubMed citation SUBMITTER
32428865 PubMed citation Europe PMC
PMC7202249 PubMed Central citation Europe PMC
PMC7242921 PubMed Central citation Europe PMC
Last Modified
03 June 2020