liproxstatin-1 (CHEBI:173097)

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ChEBI Name	liproxstatin-1

ChEBI ID	CHEBI:173097

Definition	An azaspiro compound that is 1'H-spiro[piperidine-4,2'-quinoxaline] in which the hydrogen at position 3' is replaced by a (3-chlorobenzyl)amino group. It is a potent inhibitor of ferroptosis.

Stars	This entity has been manually annotated by the ChEBI Team.

Supplier Information

Download	Molfile XML SDF

Formula

C19H21ClN4

Net Charge

Average Mass

340.860

Monoisotopic Mass

340.14547

InChI

InChI=1S/C19H21ClN4/c20-15-5-3-4-14(12-15)13-22-18-19(8-10-21-11-9-19)24-17-7-2-1-6-16(17)23-18/h1-7,12,21,24H,8-11,13H2,(H,22,23)

InChIKey

YAFQFNOUYXZVPZ-UHFFFAOYSA-N

SMILES

ClC1=CC(CNC2=NC3=CC=CC=C3NC22CCNCC2)=CC=C1

Roles Classification
Chemical Role(s):	radical scavenger A role played by a substance that can react readily with, and thereby eliminate, radicals. antioxidant A substance that opposes oxidation or inhibits reactions brought about by dioxygen or peroxides. Bronsted base A molecular entity capable of accepting a hydron from a donor (Bronsted acid). (via organic amino compound )

Biological Role(s):	ferroptosis inhibitor Any substance that inhibits the process of ferroptosis (a type of programmed cell death dependent on iron and characterized by the accumulation of lipid peroxides) in organisms.

Application(s):	cardioprotective agent Any protective agent that is able to prevent damage to the heart.

ChEBI Ontology
Outgoing	liproxstatin-1 (CHEBI:173097) has role antioxidant (CHEBI:22586) liproxstatin-1 (CHEBI:173097) has role cardioprotective agent (CHEBI:77307) liproxstatin-1 (CHEBI:173097) has role ferroptosis inhibitor (CHEBI:173084) liproxstatin-1 (CHEBI:173097) has role radical scavenger (CHEBI:48578) liproxstatin-1 (CHEBI:173097) is a azaspiro compound (CHEBI:35624) liproxstatin-1 (CHEBI:173097) is a monochlorobenzenes (CHEBI:83403) liproxstatin-1 (CHEBI:173097) is a organic heterotricyclic compound (CHEBI:26979) liproxstatin-1 (CHEBI:173097) is a secondary amino compound (CHEBI:50995)

IUPAC Name

N-(3-chlorobenzyl)-1'H-spiro[piperidine-4,2'-quinoxalin]-3'-amine

Synonyms	Sources
Lip-1	ChEBI
liproxstatin 1	ChEBI
liproxstatin1	ChEBI
N-[(3-chlorophenyl)methyl]-1'H-spiro[piperidine-4,2'-quinoxalin]-3'-amine	IUPAC

Registry Number	Type	Source
950455-15-9	CAS Registry Number	ChEBI

Last Modified

27 May 2021