|
cabotegravir |
|
CHEBI:172944 |
|
A monocarboxylic acid amide obtained by formal condensation of the carboxy group of (3S,11aR)-6-hydroxy-3-methyl-5,7-dioxo-2,3,5,7,11,11a-hexahydro[1,3]oxazolo[3,2-a]pyrido[1,2-d]pyrazine-8-carboxylic acid with the amino group of 2,4-difluorobenzylamine. Used (as its sodium salt) for treatment of HIV-1. |
|
This entity has been manually annotated by the ChEBI Team.
|
|
R. Stephan
|
|
|
|
Molfile
XML
SDF
|
|
more structures >>
|
|
|
InChI=1S/C19H17F2N3O5/c1-9-8-29-14-7-23-6-12(16(25)17(26)15(23)19(28)24(9)14)18(27)22-5-10-2-3-11(20)4-13(10)21/h2-4,6,9,14,26H,5,7-8H2,1H3,(H,22,27)/t9-,14+/m0/s1 |
WCWSTNLSLKSJPK-LKFCYVNXSA-N |
[H][C@@]12CN3C=C(C(=O)NCC4=C(F)C=C(F)C=C4)C(=O)C(O)=C3C(=O)N1[C@@H](C)CO2 |
|
HIV-1 integrase inhibitor
An inhibitor of HIV-1 integrase, an enzyme required for the integration of the genetic material of the retrovirus into the DNA of the infected cells.
|
|
View more via ChEBI Ontology
(3S,11aR)-N-(2,4-difluorobenzyl)-6-hydroxy-3-methyl-5,7-dioxo-2,3,5,7,11,11a-hexahydro[1,3]oxazolo[3,2-a]pyrido[1,2-d]pyrazine-8-carboxamide
|
cabotegravir
|
WHO MedNet
|
cabotegravir
|
WHO MedNet
|
cabotégravir
|
WHO MedNet
|
cabotegravirum
|
WHO MedNet
|
CAB
|
ChemIDplus
|
GSK 1265744
|
ChemIDplus
|
GSK 744
|
ChemIDplus
|
GSK-1265744
|
ChemIDplus
|
GSK-1265744A
|
DrugBank
|
GSK1265744
|
ChEBI
|
GSK1265744A
|
ChemIDplus
|
GSK744
|
ChemIDplus
|
GSK744 LA
|
ChemIDplus
|
GSK744 LAP
|
ChemIDplus
|
S-265744
|
ChemIDplus
|
S/GSK1265744
|
ChemIDplus
|
1051375-10-0
|
CAS Registry Number
|
ChemIDplus
|
24144896
|
PubMed citation
|
Europe PMC
|
24594934
|
PubMed citation
|
Europe PMC
|
25469523
|
PubMed citation
|
Europe PMC
|
25589630
|
PubMed citation
|
Europe PMC
|
25589631
|
PubMed citation
|
Europe PMC
|
29410019
|
PubMed citation
|
Europe PMC
|
29746267
|
PubMed citation
|
Europe PMC
|
31644481
|
PubMed citation
|
Europe PMC
|
32164474
|
PubMed citation
|
Europe PMC
|
32341511
|
PubMed citation
|
Europe PMC
|
32361755
|
PubMed citation
|
Europe PMC
|
32447500
|
PubMed citation
|
Europe PMC
|
32495274
|
PubMed citation
|
Europe PMC
|
32497490
|
PubMed citation
|
Europe PMC
|
32592669
|
PubMed citation
|
Europe PMC
|
32882042
|
PubMed citation
|
Europe PMC
|
33005698
|
PubMed citation
|
Europe PMC
|
33112699
|
PubMed citation
|
Europe PMC
|
33136751
|
PubMed citation
|
SUBMITTER
|
33148996
|
PubMed citation
|
Europe PMC
|
33289810
|
PubMed citation
|
Europe PMC
|
33308425
|
PubMed citation
|
Europe PMC
|
33347943
|
PubMed citation
|
Europe PMC
|
33593093
|
PubMed citation
|
Europe PMC
|
33730748
|
PubMed citation
|
Europe PMC
|
33770512
|
PubMed citation
|
Europe PMC
|
33770513
|
PubMed citation
|
Europe PMC
|
33794181
|
PubMed citation
|
Europe PMC
|
33821887
|
PubMed citation
|
Europe PMC
|
33822851
|
PubMed citation
|
Europe PMC
|
33830459
|
PubMed citation
|
Europe PMC
|
33872258
|
PubMed citation
|
Europe PMC
|
33957367
|
PubMed citation
|
Europe PMC
|
PMC7776404
|
PubMed Central citation
|
Europe PMC
|
|