CHEBI:142432 - vericiguat

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ChEBI Name vericiguat
ChEBI ID CHEBI:142432
Definition A pyrazolopyridine that is 5-fluoro-1H-pyrazolo[3,4-b]pyridine in which the amino hydrogen at position 1 has been substituted by a 2-fluorobenzyl group and the hydrogen at position 3 has been substituted by a 4,6-diamino-5-[(methoxycarbonyl)amino]pyrimidin-2-yl group. It is a soluble guanylate cyclase stimulator which is used for treatment of chronic heart failure.
Stars This entity has been manually annotated by the ChEBI Team.
Submitter Bijay
Supplier Information
Download Molfile XML SDF
Formula C19H16F2N8O2
Net Charge 0
Average Mass 426.380
Monoisotopic Mass 426.13643
InChI InChI=1S/C19H16F2N8O2/c1-31-19(30)25-14-15(22)26-17(27-16(14)23)13-11-6-10(20)7-24-18(11)29(28-13)8-9-4-2-3-5-12(9)21/h2-7H,8H2,1H3,(H,25,30)(H4,22,23,26,27)
InChIKey QZFHIXARHDBPBY-UHFFFAOYSA-N
SMILES N=1C(=NC(=C(C1N)NC(=O)OC)N)C=2C3=C(N(N2)CC=4C(=CC=CC4)F)N=CC(=C3)F
Roles Classification
Chemical Role(s): Bronsted base
A molecular entity capable of accepting a hydron from a donor (Bronsted acid).
(via organic amino compound )
Biological Role(s): soluble guanylate cyclase activator
Any compound that binds to and activates soluble guanylate cyclase (EC 4.6.1.2).
Application(s): vasodilator agent
A drug used to cause dilation of the blood vessels.
antihypertensive agent
Any drug used in the treatment of acute or chronic vascular hypertension regardless of pharmacological mechanism.
View more via ChEBI Ontology
ChEBI Ontology
Outgoing vericiguat (CHEBI:142432) has role antihypertensive agent (CHEBI:35674)
vericiguat (CHEBI:142432) has role soluble guanylate cyclase activator (CHEBI:76022)
vericiguat (CHEBI:142432) has role vasodilator agent (CHEBI:35620)
vericiguat (CHEBI:142432) is a aminopyrimidine (CHEBI:38338)
vericiguat (CHEBI:142432) is a carbamate ester (CHEBI:23003)
vericiguat (CHEBI:142432) is a organofluorine compound (CHEBI:37143)
vericiguat (CHEBI:142432) is a pyrazolopyridine (CHEBI:46699)
IUPAC Name
methyl {4,6-diamino-2-[5-fluoro-1-(2-fluorobenzyl)-1H-pyrazolo[3,4-b]pyridin-3-yl]pyrimidin-5-yl}carbamate
INNs Sources
vériciguat WHO MedNet
vericiguat WHO MedNet
vericiguat WHO MedNet
vericiguatum WHO MedNet
Synonyms Sources
BAY-1021189 ChemIDplus
BAY1021189 ChemIDplus
methyl N-[4,6-diamino-2-[5-fluoro-1-[(2-fluorophenyl)methyl]pyrazolo[3,4-b]pyridin-3-yl]pyrimidin-5-yl]carbamate ChEBI
MK-1242 ChEBI
Manual Xrefs Databases
D11051 KEGG DRUG
US2012022084 Patent
View more database links
Registry Numbers Types Sources
1350653-20-1 CAS Registry Number ChemIDplus
22098890 Reaxys Registry Number Reaxys
Citations Waiting for Citations Types Sources
24092345 PubMed citation Europe PMC
25056511 PubMed citation Europe PMC
25737289 PubMed citation Europe PMC
26547357 PubMed citation Europe PMC
28369340 PubMed citation Europe PMC
28557445 PubMed citation Europe PMC
29032136 PubMed citation Europe PMC
PMC4565100 PubMed Central citation Europe PMC
Last Modified
29 January 2021