4-phenyl-3-furoxancarbonitrile (CHEBI:180495)

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ChEBI Name	4-phenyl-3-furoxancarbonitrile

ChEBI ID	CHEBI:180495

Definition	A 1,2,5-oxadiazole substituted by an oxido, cyano and phenyl groups at positions 2, 3 and 4, respectively. It is a vasodilator and inhibitor of platelet aggregation.

Stars	This entity has been manually annotated by the ChEBI Team.

Supplier Information

Download	Molfile XML SDF

Formula

C9H5N3O2

Net Charge

Average Mass

187.158

Monoisotopic Mass

187.03818

InChI

InChI=1S/C9H5N3O2/c10-6-8-9(11-14-12(8)13)7-4-2-1-3-5-7/h1-5H

InChIKey

PMYJGTWUVVVOFO-UHFFFAOYSA-N

SMILES

[O-][N+]1=C(C#N)C(=NO1)C1=CC=CC=C1

Roles Classification
Chemical Role(s):	nitric oxide donor An agent, with unique chemical structure and biochemical requirements, which generates nitric oxide.

Biological Role(s):	soluble guanylate cyclase activator Any compound that binds to and activates soluble guanylate cyclase (EC 4.6.1.2).

Application(s):	geroprotector Any compound that supports healthy aging, slows the biological aging process, or extends lifespan. platelet aggregation inhibitor A drug or agent which antagonizes or impairs any mechanism leading to blood platelet aggregation, whether during the phases of activation and shape change or following the dense-granule release reaction and stimulation of the prostaglandin-thromboxane system. vasodilator agent A drug used to cause dilation of the blood vessels.

ChEBI Ontology
Outgoing	4-phenyl-3-furoxancarbonitrile (CHEBI:180495) has role geroprotector (CHEBI:176497) 4-phenyl-3-furoxancarbonitrile (CHEBI:180495) has role nitric oxide donor (CHEBI:50566) 4-phenyl-3-furoxancarbonitrile (CHEBI:180495) has role platelet aggregation inhibitor (CHEBI:50427) 4-phenyl-3-furoxancarbonitrile (CHEBI:180495) has role soluble guanylate cyclase activator (CHEBI:76022) 4-phenyl-3-furoxancarbonitrile (CHEBI:180495) has role vasodilator agent (CHEBI:35620) 4-phenyl-3-furoxancarbonitrile (CHEBI:180495) is a 1,2,5-oxadiazole (CHEBI:46815) 4-phenyl-3-furoxancarbonitrile (CHEBI:180495) is a N-oxide (CHEBI:35580) 4-phenyl-3-furoxancarbonitrile (CHEBI:180495) is a benzenes (CHEBI:22712) 4-phenyl-3-furoxancarbonitrile (CHEBI:180495) is a nitrile (CHEBI:18379)

IUPAC Name

4-phenyl-1,2,5-oxadiazole-3-carbonitrile 2-oxide

Synonyms	Sources
2-oxo-4-phenyl-1,2,5λ⁵-oxadiazole-3-carbonitrile	IUPAC
3-cyano-4-phenylfurazan 2-oxide	ChEBI
RVC-589	ChEBI

Registry Number	Type	Source
125520-62-9	CAS Registry Number	ChEBI

Last Modified

22 September 2021