A C21-steroid that is cortisone bearing an additional hydroxy substituent at the 6β-position. It is produced as a metabolite of cortisol by cytochrome p450-3A4 (CYP3A4, an important enzyme involved in the metabolism of a variety of exogenous and endogenous compounds) and can be used to detect moderate and potent CYP3A4 inhibition in vivo.
Stars
This entity has been manually annotated by the ChEBI Team.