CHEBI:74498 - 5-fluoroorotic acid

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ChEBI Name 5-fluoroorotic acid ChEBI ID CHEBI:74498 Definition A pyrimidinemonocarboxylic that is orotic acid which is substituted by fluorine at position 5. It is used in yeast molecular genetics to detect expression of the URA3 gene, which encodes orotine-5'-monophosphate dicarboxylase. A yeast with and active URA3 gene converts 5-fluoroorotic acid to fluorodeoxyuridine, which is toxic to cells. Stars This entity has been manually annotated by the ChEBI Team. Roles Classification Chemical Role(s): Bronsted acid A molecular entity capable of donating a hydron to an acceptor (Bronsted base). (via oxoacid ) View more via ChEBI Ontology ChEBI Ontology Outgoing 5-fluoroorotic acid (CHEBI:74498) is a nucleobase analogue (CHEBI:67142) 5-fluoroorotic acid (CHEBI:74498) is a organofluorine compound (CHEBI:37143) 5-fluoroorotic acid (CHEBI:74498) is a pyrimidinemonocarboxylic acid (CHEBI:26447) IUPAC Name 5-fluoro-2,6-dioxo-1,2,3,6-tetrahydropyrimidine-4-carboxylic acid Synonyms Sources 1,2,3,6-tetrahydro-2,6-dioxo-5-fluoro-4-pyrimidinecarboxylic acid ChemIDplus 5-fluoro-1,2,3,6-tetrahydro-2,6-dioxo-4-pyrimidinecarboxylic acid ChEBI 5-fluoro-6-carboxyuracil ChEBI 5-fluorouracil-4-carboxylic acid ChemIDplus ENT-26398 ChemIDplus FO ChemIDplus FOA ChemIDplus NSC 31712 ChemIDplus NSC-31712 ChEBI Ro 2-9945 ChemIDplus Manual Xrefs Databases GB806584 Patent US2948725 Patent View more database links Registry Numbers Types Sources 181933 Reaxys Registry Number Reaxys 703-95-7 CAS Registry Number ChemIDplus Citations Types Sources 2675756 PubMed citation Europe PMC 3323810 PubMed citation Europe PMC 3586772 PubMed citation Europe PMC Last Modified 03 July 2013