An organic sodium salt that is the disodium salt of N-{4-[2-(2-amino-4-oxo-4,7-dihydro-1H-pyrrolo[2,3-d]pyrimidin-5-yl)ethyl]benzoyl}-L-glutamic acid. Inhibits thymidylate synthase (TS), 421 dihydrofolate reductase (DHFR), and glycinamide ribonucleotide formyltransferase (GARFT).
Stars
This entity has been manually annotated by the ChEBI Team.
A substance which is structurally similar to a metabolite but which competes with it or replaces it, and so prevents or reduces its normal utilization.
An EC 1.5.1.* (oxidoreductase acting on donor CH-NH group, NAD+ or NADP+ as acceptor) inhibitor that interferes with the action of dihydrofolate reductase (EC 1.5.1.3).
An EC 2.1.2.* (hydroxymethyl-, formyl- and related transferases) inhibitor that interferes with the action of phosphoribosylglycinamide formyltransferase (EC 2.1.2.2).
pemetrexed disodium
(CHEBI:63722)
has part
pemetrexed(2−)
(CHEBI:63724)
pemetrexed disodium
(CHEBI:63722)
has role
antimetabolite
(CHEBI:35221)
pemetrexed disodium
(CHEBI:63722)
has role
antineoplastic agent
(CHEBI:35610)
pemetrexed disodium
(CHEBI:63722)
has role
EC 1.5.1.3 (dihydrofolate reductase) inhibitor
(CHEBI:50683)
pemetrexed disodium
(CHEBI:63722)
has role
EC 2.1.1.45 (thymidylate synthase) inhibitor
(CHEBI:63720)
pemetrexed disodium
(CHEBI:63722)
has role
EC 2.1.2.2 (phosphoribosylglycinamide formyltransferase) inhibitor
(CHEBI:63721)
pemetrexed disodium
(CHEBI:63722)
is a
organic sodium salt
(CHEBI:38700)
Incoming
pemetrexed disodium heptahydrate
(CHEBI:63723)
has part
pemetrexed disodium
(CHEBI:63722)