midodrine hydrochloride (CHEBI:31847)

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ChEBI Name	midodrine hydrochloride

ChEBI ID	CHEBI:31847

Definition	A hydrochloride resulting from the combination of equimolar amounts of midodrine and hydrogen chloride. Midodrine is a direct-acting sympathomimetic with selective α-adrenergic agonist activity. The hydrochloride salt is used as a peripheral vasoconstrictor in the treatment of certain hypotensive states. The main active moiety is its major metabolite, deglymidodrine.

Stars	This entity has been manually annotated by the ChEBI Team.

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Formulae

C12H18N2O4.HCl
C12H19ClN2O4

Net Charge

Average Mass

290.74300

Monoisotopic Mass

290.10333

InChI

InChI=1S/C12H18N2O4.ClH/c1-17-8-3-4-11(18-2)9(5-8)10(15)7-14-12(16)6-13;/h3-5,10,15H,6-7,13H2,1-2H3,(H,14,16);1H

InChIKey

MGCQZNBCJBRZDT-UHFFFAOYSA-N

SMILES

Cl.COc1ccc(OC)c(c1)C(O)CNC(=O)CN

Roles Classification
Biological Role(s):	alpha-adrenergic agonist An agent that selectively binds to and activates alpha-adrenergic receptors. sympathomimetic agent A drug that mimics the effects of stimulating postganglionic adrenergic sympathetic nerves. Included in this class are drugs that directly stimulate adrenergic receptors and drugs that act indirectly by provoking the release of adrenergic transmitters.

Application(s):	alpha-adrenergic agonist An agent that selectively binds to and activates alpha-adrenergic receptors. sympathomimetic agent A drug that mimics the effects of stimulating postganglionic adrenergic sympathetic nerves. Included in this class are drugs that directly stimulate adrenergic receptors and drugs that act indirectly by provoking the release of adrenergic transmitters. vasoconstrictor agent Drug used to cause constriction of the blood vessels.

ChEBI Ontology
Outgoing	midodrine hydrochloride (CHEBI:31847) has part midodrine(1+) (CHEBI:73243) midodrine hydrochloride (CHEBI:31847) has role α-adrenergic agonist (CHEBI:35569) midodrine hydrochloride (CHEBI:31847) has role sympathomimetic agent (CHEBI:35524) midodrine hydrochloride (CHEBI:31847) has role vasoconstrictor agent (CHEBI:50514) midodrine hydrochloride (CHEBI:31847) is a hydrochloride (CHEBI:36807)

IUPAC Name

rac-N-[2-(2,5-dimethoxyphenyl)-2-hydroxyethyl]glycinamide hydrochloride

Synonyms	Sources
(+-)-1-(2',5'-Dimethoxyphenyl)-2-glycinamidoethanol hydrochloride	ChemIDplus
(+-)-2-Amino-N-(beta-hydroxy-2,5-dimethoxyphenethyl)acetamide monohydrochloride	ChemIDplus
(+-)-Midodrine hydrochloride	ChemIDplus
Midodrine HCl	ChemIDplus

Last Modified

19 April 2013