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CHEBI:9728 - trimethaphan
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ChEBI Name
trimethaphan
ChEBI ID
CHEBI:9728
Definition
A complex heterocyclic sulfonium compound with an imidazolium core, used to treat hypertension.
Stars
This entity has been manually annotated by the ChEBI Team.
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Formula
C22H25N2OS
Net Charge
+1
Average Mass
365.51200
Monoisotopic Mass
365.16821
InChI
InChI=1S/C22H25N2OS/c25-
22-
23(14-
17-
8-
3-
1-
4-
9-
17)
19-
16-
26-
13-
7-
12-
20(26)
21(19)
24(22)
15-
18-
10-
5-
2-
6-
11-
18/h1-
6,8-
11,19-
21H,7,12-
16H2/q+1
InChIKey
CHQOEHPMXSHGCL-UHFFFAOYSA-N
SMILES
O=C1N(Cc2ccccc2)C2C[S+]3CCCC3C2N1Cc1ccccc1
Roles Classification
Biological Role
(s):
nicotinic antagonist
An antagonist at the nicotinic cholinergic receptor.
Application
(s):
anaesthesia adjuvant
Any substance that possesses little anaesthetic effect by itself, but which enhances or potentiates the anaesthetic action of other drugs when given at the same time.
vasodilator agent
A drug used to cause dilation of the blood vessels.
antihypertensive agent
Any drug used in the treatment of acute or chronic vascular hypertension regardless of pharmacological mechanism.
nicotinic antagonist
An antagonist at the nicotinic cholinergic receptor.
View more via ChEBI Ontology
ChEBI Ontology
Outgoing
trimethaphan (
CHEBI:9728
)
has role
anaesthesia adjuvant (
CHEBI:60807
)
trimethaphan (
CHEBI:9728
)
has role
antihypertensive agent (
CHEBI:35674
)
trimethaphan (
CHEBI:9728
)
has role
nicotinic antagonist (
CHEBI:48878
)
trimethaphan (
CHEBI:9728
)
has role
vasodilator agent (
CHEBI:35620
)
trimethaphan (
CHEBI:9728
)
is a
sulfonium compound (
CHEBI:26830
)
Incoming
trimethaphan camsylate (
CHEBI:9729
)
has part
trimethaphan (
CHEBI:9728
)
IUPAC Name
1,3-dibenzyl-2-oxodecahydrothieno[1',2':1,2]thieno[3,4-d]imidazol-5-ium
Synonyms
Sources
Trimetaphan
ChemIDplus
Trimetaphanum
ChemIDplus
Trimethaphan
KEGG COMPOUND
Manual Xrefs
Databases
2752
DrugCentral
C07174
KEGG COMPOUND
DB01116
DrugBank
View more database links
Registry Number
Type
Source
7187-66-8
CAS Registry Number
ChemIDplus
Last Modified
22 February 2017