GW296115X (CHEBI:143121)

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ChEBI Name	GW296115X

ChEBI ID	CHEBI:143121

Definition	An indolocarbazole compound having methoxy groups at positions 3 and 9 and an additional fused pyrrolidine-2,5-dione ring. It is an inhibitor of BRSK2 kinase, PDGF-dependent receptor autophosphorylation and cell proliferation.

Stars	This entity has been manually annotated by the ChEBI Team.

Submitter	Tim Willson

Supplier Information

Download	Molfile XML SDF

Formula

C22H15N3O4

Net Charge

Average Mass

385.379

Monoisotopic Mass

385.10626

InChI

InChI=1S/C22H15N3O4/c1-28-9-3-5-13-11(7-9)15-17-18(22(27)25-21(17)26)16-12-8-10(29-2)4-6-14(12)24-20(16)19(15)23-13/h3-8,23-24H,1-2H3,(H,25,26,27)

InChIKey

LGTURXDQKJRHSF-UHFFFAOYSA-N

SMILES

COC1=CC2=C(NC3=C2C4=C(C(NC4=O)=O)C5=C3NC6=C5C=C(OC)C=C6)C=C1

Roles Classification
Biological Role(s):	EC 2.7.11.1 (non-specific serine/threonine protein kinase) inhibitor An EC 2.7.11.* (protein-serine/threonine kinase) inhibitor that interferes with the action of non-specific serine/threonine protein kinase (EC 2.7.11.1), a kinase enzyme involved in phosphorylation of hydroxy group of serine or threonine.

ChEBI Ontology
Outgoing	GW296115X (CHEBI:143121) has role EC 2.7.11.1 (non-specific serine/threonine protein kinase) inhibitor (CHEBI:50925) GW296115X (CHEBI:143121) is a aromatic ether (CHEBI:35618) GW296115X (CHEBI:143121) is a indolocarbazole (CHEBI:51915) GW296115X (CHEBI:143121) is a organic heterohexacyclic compound (CHEBI:51914)

IUPAC Name

3,9-dimethoxy-12,13-dihydro-5H-indolo[2,3-a]pyrrolo[3,4-c]carbazole-5,7(6H)-dione

Synonyms	Sources
12,13-dihydro-3,9-dimethoxy-5H-Indolo[2,3-a]pyrrolo[3,4-c]carbazole-5,7(6H)-dione	ChEBI
3744-W	ChEBI
3744W	ChEBI
GW296115	ChEBI
GW296115X	ChEBI

Registry Number	Type	Source
118458-58-5	CAS Registry Number	ChEBI

Last Modified

07 March 2019