DMH1 (CHEBI:86289)

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ChEBI Name	DMH1

ChEBI ID	CHEBI:86289

Definition	A pyrazolopyrimidine that is pyrazolo[1,5-a]pyrimidine bearing quinolin-4-yl and 4-isopropyloxyphenyl substituents at positions 3 and 6 respectively.

Stars	This entity has been manually annotated by the ChEBI Team.

Submitter	Ceri

Supplier Information

Download	Molfile XML SDF

Formula

C24H20N4O

Net Charge

Average Mass

380.44180

Monoisotopic Mass

380.16371

InChI

InChI=1S/C24H20N4O/c1-16(2)29-19-9-7-17(8-10-19)18-13-26-24-22(14-27-28(24)15-18)20-11-12-25-23-6-4-3-5-21(20)23/h3-16H,1-2H3

InChIKey

JMIFGARJSWXZSH-UHFFFAOYSA-N

SMILES

CC(C)Oc1ccc(cc1)-c1cnc2c(cnn2c1)-c1ccnc2ccccc12

Roles Classification
Biological Role(s):	bone morphogenetic protein receptor antagonist An antagonist at the bone morphogenetic protein receptor. protein kinase inhibitor An EC 2.7.* (P-containing group transferase) inhibitor that interferes with the action of protein kinases.

Application(s):	antineoplastic agent A substance that inhibits or prevents the proliferation of neoplasms.

ChEBI Ontology
Outgoing	DMH1 (CHEBI:86289) has role antineoplastic agent (CHEBI:35610) DMH1 (CHEBI:86289) has role bone morphogenetic protein receptor antagonist (CHEBI:78623) DMH1 (CHEBI:86289) has role protein kinase inhibitor (CHEBI:37699) DMH1 (CHEBI:86289) is a aromatic ether (CHEBI:35618) DMH1 (CHEBI:86289) is a pyrazolopyrimidine (CHEBI:38669) DMH1 (CHEBI:86289) is a quinolines (CHEBI:26513)

IUPAC Name

4-(6-{4-[(propan-2-yl)oxy]phenyl}pyrazolo[1,5-a]pyrimidin-3-yl)quinoline

Registry Number	Type	Source
20934957	Reaxys Registry Number	Reaxys

Last Modified

06 July 2016