CHEBI:51368 - lofexidine

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ChEBI Name lofexidine
ChEBI ID CHEBI:51368
Stars This entity has been manually annotated by the ChEBI Team.
Supplier Information
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Formula C11H12Cl2N2O
Net Charge 0
Average Mass 259.13126
Monoisotopic Mass 258.03267
InChI InChI=1S/C11H12Cl2N2O/c1-7(11-14-5-6-15-11)16-10-8(12)3-2-4-9(10)13/h2-4,7H,5-6H2,1H3,(H,14,15)
InChIKey KSMAGQUYOIHWFS-UHFFFAOYSA-N
SMILES CC(Oc1c(Cl)cccc1Cl)C1=NCCN1
Roles Classification
Biological Role(s): alpha-adrenergic agonist
An agent that selectively binds to and activates alpha-adrenergic receptors.
Application(s): alpha-adrenergic agonist
An agent that selectively binds to and activates alpha-adrenergic receptors.
antihypertensive agent
Any drug used in the treatment of acute or chronic vascular hypertension regardless of pharmacological mechanism.
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ChEBI Ontology
Outgoing lofexidine (CHEBI:51368) has role α-adrenergic agonist (CHEBI:35569)
lofexidine (CHEBI:51368) has role antihypertensive agent (CHEBI:35674)
lofexidine (CHEBI:51368) is a aromatic ether (CHEBI:35618)
lofexidine (CHEBI:51368) is a carboxamidine (CHEBI:35359)
lofexidine (CHEBI:51368) is a dichlorobenzene (CHEBI:23697)
lofexidine (CHEBI:51368) is a imidazoles (CHEBI:24780)
IUPAC Name
2-[1-(2,6-dichlorophenoxy)ethyl]-4,5-dihydro-1H-imidazole
INNs Sources
lofexidina WHO MedNet
lofexidine WHO MedNet
lofexidine ChemIDplus
lofexidinum WHO MedNet
Synonym Source
2-(alpha-(2,6-Dichlorophenoxy)ethyl)2-imidazoline ChemIDplus
Manual Xrefs Databases
1593 DrugCentral
DB04948 DrugBank
DE1935479 Patent
LSM-4951 LINCS
US3966757 Patent
View more database links
Registry Numbers Types Sources
31036-80-3 CAS Registry Number ChemIDplus
750704 Beilstein Registry Number Beilstein
Last Modified
22 February 2017