CHEBI:167674 - tesevatinib

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ChEBI Name tesevatinib
ChEBI ID CHEBI:167674
Definition A member of the class of quinazolines that is quinazoline substituted by (3,4-dichloro-2-fluorophenyl)amino, methoxy, and [(3aR,5r,6aS)-2-methyloctahydrocyclopenta[c]pyrrol-5-yl]methoxy groups at positions 4, 6 and 7, respectively. It is a multi-target tyrosine kinase inhibitor of EGFR, ErbB2, KDR, Flt4 and EphB4 and exhibits anti-cancer properties.
Stars This entity has been manually annotated by the ChEBI Team.
Submitter R. Stephan
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Formula C24H25Cl2FN4O2
Net Charge 0
Average Mass 491.390
Monoisotopic Mass 490.13386
InChI InChI=1S/C24H25Cl2FN4O2/c1-31-9-14-5-13(6-15(14)10-31)11-33-21-8-19-16(7-20(21)32-2)24(29-12-28-19)30-18-4-3-17(25)22(26)23(18)27/h3-4,7-8,12-15H,5-6,9-11H2,1-2H3,(H,28,29,30)/t13-,14-,15+
InChIKey HVXKQKFEHMGHSL-QKDCVEJESA-N
SMILES [H][C@@]1(COC2=C(OC)C=C3C(NC4=C(F)C(Cl)=C(Cl)C=C4)=NC=NC3=C2)C[C@]2([H])CN(C)C[C@]2([H])C1
Roles Classification
Chemical Role(s): Bronsted base
A molecular entity capable of accepting a hydron from a donor (Bronsted acid).
(via organic amino compound )
Biological Role(s): EC 2.7.10.1 (receptor protein-tyrosine kinase) inhibitor
An EC 2.7.10.* (protein-tyrosine kinase) inhibitor that interferes with the action of receptor protein-tyrosine kinase (EC 2.7.10.1).
epidermal growth factor receptor antagonist
An antagonist at the epidermal growth factor receptor.
Application(s): antineoplastic agent
A substance that inhibits or prevents the proliferation of neoplasms.
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ChEBI Ontology
Outgoing tesevatinib (CHEBI:167674) has role antineoplastic agent (CHEBI:35610)
tesevatinib (CHEBI:167674) has role EC 2.7.10.1 (receptor protein-tyrosine kinase) inhibitor (CHEBI:62434)
tesevatinib (CHEBI:167674) has role epidermal growth factor receptor antagonist (CHEBI:74440)
tesevatinib (CHEBI:167674) is a aromatic ether (CHEBI:35618)
tesevatinib (CHEBI:167674) is a dichlorobenzene (CHEBI:23697)
tesevatinib (CHEBI:167674) is a diether (CHEBI:46786)
tesevatinib (CHEBI:167674) is a monofluorobenzenes (CHEBI:83575)
tesevatinib (CHEBI:167674) is a quinazolines (CHEBI:38530)
tesevatinib (CHEBI:167674) is a secondary amino compound (CHEBI:50995)
tesevatinib (CHEBI:167674) is a tertiary amino compound (CHEBI:50996)
IUPAC Name
N-(3,4-dichloro-2-fluorophenyl)-6-methoxy-7-{[(3aR,5r,6aS)-2-methyloctahydrocyclopenta[c]pyrrol-5-yl]methoxy}quinazolin-4-amine
INNs Sources
tesevatinib WHO MedNet
tésévatinib WHO MedNet
tesevatinib WHO MedNet
tesevatinibum WHO MedNet
Synonyms Sources
7-{[(3aR,5R,6aS)-2-methyl-octahydrocyclopenta[c]pyrrol-5-yl]methoxy}-N-(3,4-dichloro-2-fluorophenyl)-6-methoxyquinazolin-4-amine IUPAC
EXEL 7647 ChemIDplus
EXEL-7647 ChemIDplus
EXEL7647 ChEBI
KD 019 ChemIDplus
KD-019 ChemIDplus
KD019 ChemIDplus
XL 647 ChemIDplus
XL-647 ChemIDplus
XL647 ChemIDplus
Manual Xrefs Databases
32699556 ChemSpider
D11772 KEGG DRUG
DB11973 DrugBank
Tesevatinib Wikipedia
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Registry Numbers Types Sources
781613-23-8 CAS Registry Number ChemIDplus
781613-23-8 CAS Registry Number KEGG DRUG
Citations Waiting for Citations Types Sources
17575237 PubMed citation SUBMITTER
18413839 PubMed citation Europe PMC
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23411383 PubMed citation Europe PMC
28729967 PubMed citation SUBMITTER
30030583 PubMed citation Europe PMC
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Last Modified
15 March 2021