CHEBI:7550 - nicardipine

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ChEBI Name nicardipine
ChEBI ID CHEBI:7550
Definition A racemate comprising equimolar amounts of (R)- and (S)-nicardipine. It is a calcium channel blocker which is used to treat hypertension.
Stars This entity has been manually annotated by the ChEBI Team.
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Formula C26H29N3O6
Net Charge 0
Average Mass 479.533
Monoisotopic Mass 479.20564
Roles Classification
Biological Role(s): calcium channel blocker
One of a class of drugs that acts by selective inhibition of calcium influx through cell membranes or on the release and binding of calcium in intracellular pools.
autophagy inhibitor
Any compound that inhibits the process of autophagy (the self-digestion of one or more components of a cell through the action of enzymes originating within the same cell).
Application(s): antihypertensive agent
Any drug used in the treatment of acute or chronic vascular hypertension regardless of pharmacological mechanism.
vasodilator agent
A drug used to cause dilation of the blood vessels.
View more via ChEBI Ontology
ChEBI Ontology
Outgoing nicardipine (CHEBI:7550) has part (R)-nicardipine (CHEBI:180904)
nicardipine (CHEBI:7550) has part (S)-nicardipine (CHEBI:135777)
nicardipine (CHEBI:7550) has role antihypertensive agent (CHEBI:35674)
nicardipine (CHEBI:7550) has role autophagy inhibitor (CHEBI:88230)
nicardipine (CHEBI:7550) has role calcium channel blocker (CHEBI:38215)
nicardipine (CHEBI:7550) has role vasodilator agent (CHEBI:35620)
nicardipine (CHEBI:7550) is a racemate (CHEBI:60911)
IUPAC Name
2-[benzyl(methyl)amino]ethyl methyl (4RS)-2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate
INNs Sources
nicardipine WHO MedNet
nicardipine WHO MedNet
nicardipineum WHO MedNet
nicardipino WHO MedNet
Synonyms Sources
(±)-nicardipine DrugCentral
(RS)-nicardipine ChEBI
perpidine DrugCentral
rac-nicardipine ChEBI
racemic nicardipine ChEBI
YC-93 free base ChEBI
Manual Xrefs Databases
1909 DrugCentral
4319 ChemSpider
C07264 KEGG COMPOUND
D08270 KEGG DRUG
DB00622 DrugBank
HMDB0014760 HMDB
LSM-1418 LINCS
Nicardipine Wikipedia
View more database links
Registry Numbers Types Sources
504321 Reaxys Registry Number Reaxys
55985-32-5 CAS Registry Number ChemIDplus
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Last Modified
14 October 2021