CHEBI:68564 - icatibant acetate

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ChEBI Name icatibant acetate
ChEBI ID CHEBI:68564
Definition An acetate salt obtained by combining icatibant with acetic acid. Used for the treatment of acute attacks of hereditary angioedema in adult patients.
Stars This entity has been manually annotated by the ChEBI Team.
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Formula (C2H4O2)n.C59H89N19O13S
Net Charge 0
Roles Classification
Biological Role(s): beta-adrenergic antagonist
An agent that binds to but does not activate beta-adrenergic receptors thereby blocking the actions of endogenous or exogenous beta-adrenergic agonists. beta-Adrenergic antagonists are used for treatment of hypertension, cardiac arrhythmias, angina pectoris, glaucoma, migraine headaches and anxiety.
bradykinin receptor antagonist
An antagonist at the bradykinin receptor.
peptidomimetic
A small protein-like chain designed to mimic a peptide.
Application(s): beta-adrenergic antagonist
An agent that binds to but does not activate beta-adrenergic receptors thereby blocking the actions of endogenous or exogenous beta-adrenergic agonists. beta-Adrenergic antagonists are used for treatment of hypertension, cardiac arrhythmias, angina pectoris, glaucoma, migraine headaches and anxiety.
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ChEBI Ontology
Outgoing icatibant acetate (CHEBI:68564) has part icatibant (CHEBI:68556)
icatibant acetate (CHEBI:68564) has role β-adrenergic antagonist (CHEBI:35530)
icatibant acetate (CHEBI:68564) has role bradykinin receptor antagonist (CHEBI:68557)
icatibant acetate (CHEBI:68564) has role peptidomimetic (CHEBI:63175)
icatibant acetate (CHEBI:68564) is a acetate salt (CHEBI:59230)
Synonyms Sources
(R)-arginyl-(S)-arginyl-()-prolyl-(2S,4R)-(4-hydroxyprolyl)glycyl-(S)-(3-(2-thienyl)alanyl)-(S)-seryl-(R)-((1,2,3,4-tetrahydro-3-isoquinolyl)carbonyl)-(2S,3aS,7aS)-((hexahydro-2-indolinyl)carbonyl)-(S)-arginine acetate ChemIDplus
HOE 140 ChemIDplus
Brand Name Source
Firazyr KEGG DRUG
Manual Xrefs Databases
D04492 KEGG DRUG
DB06196 DrugBank
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Registry Number Type Source
138614-30-9 CAS Registry Number ChemIDplus
Citations Waiting for Citations Types Sources
19878667 PubMed citation Europe PMC
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Last Modified
08 October 2018