nagilactone F (CHEBI:68293)

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ChEBI Name	nagilactone F

ChEBI ID	CHEBI:68293

Definition	A diterpene lactone isolated from Podocarpus latifolius and has been shown to exhibit inhibitory activity against activator protein 1 (AP-1).

Stars	This entity has been manually annotated by the ChEBI Team.

Supplier Information

Download	Molfile XML SDF

Formula

C19H24O4

Net Charge

Average Mass

316.39150

Monoisotopic Mass

316.16746

InChI

InChI=1S/C19H24O4/c1-10(2)15-11-8-13-16-18(3,12(11)9-14(20)23-15)6-5-7-19(16,4)17(21)22-13/h8-10,13,15-16H,5-7H2,1-4H3/t13-,15-,16-,18-,19+/m1/s1

InChIKey

DYJDPNXKUMPXEJ-DZLVSBGCSA-N

SMILES

[H][C@@]12OC(=O)[C@@]3(C)CCC[C@](C)(C4=CC(=O)O[C@H](C(C)C)C4=C1)[C@@]23[H]

Metabolite of Species	Details
Podocarpus latifolius (NCBI:txid120620)	Found in root (BTO:0001188). Previous component: root bark; CH2Cl2-MeOH(1:1) extract of dried, ground root bark See: PubMed

Roles Classification
Biological Role(s):	metabolite Any intermediate or product resulting from metabolism. The term 'metabolite' subsumes the classes commonly known as primary and secondary metabolites. AP-1 antagonist An antogonist that interferes with the action of activator protein 1 (AP-1).

ChEBI Ontology
Outgoing	nagilactone F (CHEBI:68293) has role AP-1 antagonist (CHEBI:67199) nagilactone F (CHEBI:68293) has role metabolite (CHEBI:25212) nagilactone F (CHEBI:68293) is a γ-lactone (CHEBI:37581) nagilactone F (CHEBI:68293) is a δ-lactone (CHEBI:18946) nagilactone F (CHEBI:68293) is a diterpene lactone (CHEBI:49193) nagilactone F (CHEBI:68293) is a organic heterotetracyclic compound (CHEBI:38163)

IUPAC Name

(3aS,5aR,7R,10bS,10cR)-3a,10b-dimethyl-7-(propan-2-yl)-1,2,3,3a,5a,7,10b,10c-octahydro-4H,9H-[2]benzofuro[7,1-fg]isochromene-4,9-dione

Last Modified

21 August 2013