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Crystal structure of Human histone acetytransferas 1 (HAT1) in complex with isobutryl-COA and K12A mutant variant of histone H4

X-ray diffraction
1.6Å resolution
PDB entry 6vo5 coloured by chain, front view.
PDB entry 6vo5 coloured by chain, side view.
PDB entry 6vo5 coloured by chain, top view.
Source organism: Homo sapiens
Assembly composition:
hetero dimer (preferred)
Entry contents: 2 distinct polypeptide molecules

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Assemblies

Assembly 1 (preferred)
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Assembly Name: Histone acetyltransferase type B catalytic subunit and Histone H4
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Multimeric state: hetero dimer
Accessible surface area: 16813.06 Å2
Buried surface area: 3208.55 Å2
Dissociation area: 738.01 Å2
Dissociation energy (ΔGdiss): 2.92 kcal/mol
Dissociation entropy (TΔSdiss): 8.31 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-127202
Assembly 2
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Assembly Name: Histone acetyltransferase type B catalytic subunit and Histone H4
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Multimeric state: hetero dimer
Accessible surface area: 16628.78 Å2
Buried surface area: 3323.97 Å2
Dissociation area: 720.06 Å2
Dissociation energy (ΔGdiss): 1.9 kcal/mol
Dissociation entropy (TΔSdiss): 8.07 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-127202

Macromolecules

Histone acetyltransferase type B catalytic subunit
Chains: A, B
Length: 324 amino acids
Theoretical weight: 38.14 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: O14929 (Residues: 20-341; Coverage: 77%)
  • Best match: O14929-2 (Residues: 1-256)
Gene names: HAT1, KAT1
Pfam:
InterPro:
Histone acetyltransferase type B catalytic subunit in PDB entry 6vo5, assembly 1, front view.
Histone acetyltransferase type B catalytic subunit in PDB entry 6vo5, assembly 1, side view.
Histone acetyltransferase type B catalytic subunit in PDB entry 6vo5, assembly 1, top view.
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Histone H4
Chains: C, D
Length: 20 amino acids
Theoretical weight: 1.94 KDa
Source organism: Homo sapiens
Expression system: Not provided
UniProt:
  • Canonical: P62805 (Residues: 2-21; Coverage: 19%)
Gene names: H4-16, H4/A, H4/B, H4/C, H4/D, H4/E, H4/G, H4/H, H4/I, H4/J, H4/K, H4/M, H4/N, H4/O, H4C1, H4C11, H4C12, H4C13, H4C14, H4C15, H4C16, H4C2, H4C3, H4C4, H4C5, H4C6, H4C8, H4C9, H4F2, H4FA, H4FB, H4FC, H4FD, H4FE, H4FG, H4FH, H4FI, H4FJ, H4FK, H4FM, H4FN, H4FO, HIST1H4A, HIST1H4B, HIST1H4C, HIST1H4D, HIST1H4E, HIST1H4F, HIST1H4H, HIST1H4I, HIST1H4J, HIST1H4K, HIST1H4L, HIST2H4, HIST2H4A, HIST2H4B, HIST4H4
InterPro: Histone H4, conserved site
Histone H4 in PDB entry 6vo5, assembly 1, front view.
Histone H4 in PDB entry 6vo5, assembly 1, side view.
Histone H4 in PDB entry 6vo5, assembly 1, top view.
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