Conserved Site

Histone H4, conserved site (IPR019809)

Short name: Histone_H4_CS


Histone H4 is one of the four histones, along with H2A, H2B and H3, which form the eukaryotic nucleosome core. Along with H3, it plays a central role in nucleosome formation. The sequence of histone H4 has remained almost invariant in more then 2 billion years of evolution [PMID: 8121801]. The signature pattern for this entry is a pentapeptide found in positions 14 to 18 of all H4 sequences. It contains a lysine residue which is often acetylated [PMID: 6808351] and a histidine residue which is implicated in DNA-binding [PMID: 3340182].

GO terms

Biological Process

GO:0006334 nucleosome assembly

Molecular Function

GO:0003677 DNA binding

Cellular Component

GO:0000786 nucleosome
GO:0005634 nucleus

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
PROSITE patterns