Family

Histone acetyltransferase type B, catalytic subunit (IPR017380)

Short name: Hist_AcTrfase_B-typ_cat-su

Overlapping homologous superfamilies

Family relationships

None.

Description

This entry represents the catalytic subunit of histone acetyltransferase type B (EC:2.3.1.48) (also known as HAT1), which is the catalytic component of the histone acetylase B (HAT-B) complex [PMID: 18601901, PMID: 18373695, PMID: 17694075]. The HAT-B complex is composed of at least HAT1 and HAT2. In the cytoplasm, this complex binds to the histone H4 tail. In the nucleus, the HAT-B complex has an additional component, the histone H3/H4 chaperone HIF1.

This enzyme acetylates soluble but not nucleosomal H4 at Lys-12, which is required for telomeric silencing. HAT1 has intrinsic substrate specificity that modifies lysine in recognition sequence GXGKXG. It is involved in DNA double-strand break repair [PMID: 12417736].

GO terms

Biological Process

GO:0006348 chromatin silencing at telomere
GO:0016573 histone acetylation

Molecular Function

GO:0004402 histone acetyltransferase activity

Cellular Component

GO:0005634 nucleus

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
PIRSF
PANTHER