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Rabbit Muscle L-lactate dehydrogenase in complex with malonate

Source organism: Oryctolagus cuniculus
Biochemical function: oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
Biological process: carboxylic acid metabolic process
Cellular component: cytoplasm

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EC 1.1.1.27: L-lactate dehydrogenase

Reaction catalysed:
(S)-lactate + NAD(+) = pyruvate + NADH
Systematic name:
(S)-lactate:NAD(+) oxidoreductase
Alternative Name(s):
  • L(+)-nLDH
  • L-(+)-lactate dehydrogenase
  • L-lactic acid dehydrogenase
  • L-lactic dehydrogenase
  • Lactate dehydrogenase
  • Lactate dehydrogenase NAD-dependent
  • Lactic acid dehydrogenase
  • Lactic dehydrogenase
  • NAD-lactate dehydrogenase

GO terms

Sequence families

Pfam Protein families (Pfam)
PF02866
Domain description: lactate/malate dehydrogenase, alpha/beta C-terminal domain
Occurring in:
  1. L-lactate dehydrogenase A chain
The deposited structure of PDB entry 5nqb contains 4 copies of Pfam domain PF02866 (lactate/malate dehydrogenase, alpha/beta C-terminal domain) in L-lactate dehydrogenase A chain. Showing 1 copy in chain A.

PF00056
Domain description: lactate/malate dehydrogenase, NAD binding domain
Occurring in:
  1. L-lactate dehydrogenase A chain
The deposited structure of PDB entry 5nqb contains 4 copies of Pfam domain PF00056 (lactate/malate dehydrogenase, NAD binding domain) in L-lactate dehydrogenase A chain. Showing 1 copy in chain A.

InterPro InterPro annotations
IPR001557
Domain description: L-lactate/malate dehydrogenase
Occurring in:
  1. L-lactate dehydrogenase A chain
IPR015955
Domain description: Lactate dehydrogenase/glycoside hydrolase, family 4, C-terminal
Occurring in:
  1. L-lactate dehydrogenase A chain
IPR011304
Domain description: L-lactate dehydrogenase
Occurring in:
  1. L-lactate dehydrogenase A chain
IPR018177
Domain description: L-lactate dehydrogenase, active site
Occurring in:
  1. L-lactate dehydrogenase A chain
IPR022383
Domain description: Lactate/malate dehydrogenase, C-terminal
Occurring in:
  1. L-lactate dehydrogenase A chain
IPR001236
Domain description: Lactate/malate dehydrogenase, N-terminal
Occurring in:
  1. L-lactate dehydrogenase A chain
IPR036291
Domain description: NAD(P)-binding domain superfamily
Occurring in:
  1. L-lactate dehydrogenase A chain

Structure domains

CATH CATH domains
3.90.110.10
Class: Alpha Beta
Architecture: Alpha-Beta Complex
Topology: L-2-Hydroxyisocaproate Dehydrogenase; Chain A, domain 2
Homology: Lactate dehydrogenase/glycoside hydrolase, family 4, C-terminal
Occurring in:
  1. L-lactate dehydrogenase A chain
The deposited structure of PDB entry 5nqb contains 4 copies of CATH domain 3.90.110.10 (L-2-Hydroxyisocaproate Dehydrogenase; Chain A, domain 2) in L-lactate dehydrogenase A chain. Showing 1 copy in chain A.
3.40.50.720
Class: Alpha Beta
Architecture: 3-Layer(aba) Sandwich
Topology: Rossmann fold
Homology: NAD(P)-binding Rossmann-like Domain
Occurring in:
  1. L-lactate dehydrogenase A chain
The deposited structure of PDB entry 5nqb contains 4 copies of CATH domain 3.40.50.720 (Rossmann fold) in L-lactate dehydrogenase A chain. Showing 1 copy in chain A.

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