Homologous Superfamily

NAD(P)-binding domain superfamily (IPR036291)

Short name: NAD(P)-bd_dom_sf

Description

This entry represents NAD- and NADP-binding domains superfamily with a core Rossmann-type fold, which consists of three layers (alpha/beta/alpha) with parallel beta-sheet of 6 strands. Many different enzymes contain an NAD/NADP-binding domain, including:

  • C-terminal domain of alcohol dehydrogenases [PMID: 15449945]
  • Tyrosine-dependent oxidoreductases (also known as short-chain dehydrogenases) [PMID: 9174344]
  • N-terminal domain of glyceraldehyde-3-phosphate dehydrogenase [PMID: 10448043]
  • NAD-binding domain of formate/glycerate dehydrogenases [PMID: 8114093]
  • N-terminal domain of sirohaem synthase [PMID: 14595395]
  • N-terminal domain of lactate dehydrogenase [PMID: 11276087]
  • N-terminal domain of 6-phosphogluconate dehydrogenase (the beta-sheet is extended to 8 strands) [PMID: 17222187]
  • C-terminal domain of amino acid dehydrogenases (an extra N-terminal helix displaces the C-terminal helix [PMID: 8591026]
  • NAD-binding domain of certain potassium channels [PMID: 11301020]
  • C-terminal domain of the transcriptional repressor Rex [PMID: 15642260]
  • Ornithine cyclodeaminase [PMID: 15518536]
  • CoA-binding N-terminal domain of the alpha chain of succinyl-CoA synthetase [PMID: 9917402]

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
SUPERFAMILY