Domain

Lactate dehydrogenase/glycoside hydrolase, family 4, C-terminal (IPR015955)

Short name: Lactate_DH/Glyco_Ohase_4_C

Domain relationships

Description

This entry represents a structural motif found at the C-terminal of lactate dehydrogenase (EC:1.1.1.27)and malate dehydrogenases (EC:1.1.1.37), as well as at the C-terminal of family 4 glycoside hydrolases (EC:3.2.1). These domains have an unusual fold consisting of segregated alpha-helical and beta-sheet regions, although they contain predominantly anti-parallel beta-sheets [PMID: 11276087, PMID: 8117664, PMID: 12588867].

L-lactate dehydrogenases are metabolic enzymes that catalyse the conversion of L-lactate to pyruvate, the last step in anaerobic glycolysis. L-lactate dehydrogenase is also found as a lens crystallin in bird and crocodile eyes. Malate dehydrogenases catalyse the interconversion of malate to oxaloacetate. The enzyme participates in the citric acid cycle.

O-Glycosyl hydrolases EC:3.2.1. are a widespread group of enzymes that hydrolyse the glycosidic bond between two or more carbohydrates, or between a carbohydrate and a non-carbohydrate moiety. A classification system for glycosyl hydrolases, based on sequence similarity, has led to the definition of 85 different families [PMID: 7624375, PMID: 8535779, ]. This classification is available on the CAZy (CArbohydrate-Active EnZymes) web site. Because the fold of proteins is better conserved than their sequences, some of the families can be grouped in 'clans'. Glycoside hydrolase family 4 GH4 comprises enzymes with several known activities; 6-phospho-beta-glucosidase (EC:3.2.1.86); 6-phospho-alpha-glucosidase (EC:3.2.1.122); alpha-galactosidase (EC:3.2.1.22).

GO terms

Biological Process

GO:0005975 carbohydrate metabolic process
GO:0055114 oxidation-reduction process

Molecular Function

GO:0003824 catalytic activity
GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
SUPERFAMILY
GENE3D