Pathways & interactions
Lactate dehydrogenase/glycoside hydrolase, family 4, C-terminal (IPR015955)
Short name: Lactate_DH/Glyco_Ohase_4_C
- Glycoside hydrolase, family 4 (IPR001088)
- L-lactate/malate dehydrogenase (IPR001557)
- Malate dehydrogenase, type 1 (IPR010097)
- Malate dehydrogenase, type 2 (IPR010945)
- Lactate dehydrogenase, protist (IPR011272)
- Malate dehydrogenase, NADP-dependent, plants (IPR011273)
- Malate dehydrogenase, NAD-dependent, cytosolic (IPR011274)
- Malate dehydrogenase, type 3 (IPR011275)
- L-lactate dehydrogenase (IPR011304)
- Lactate/malate dehydrogenase, C-terminal (IPR022383)
- Glycosyl hydrolase, family 4, C-terminal (IPR022616)
- Malate dehydrogenase, type 1, bacterial (IPR023958)
This entry represents a structural motif found at the C-terminal of lactate dehydrogenase (EC:220.127.116.11)and malate dehydrogenases (EC:18.104.22.168), as well as at the C-terminal of family 4 glycoside hydrolases (EC:3.2.1). These domains have an unusual fold consisting of segregated alpha-helical and beta-sheet regions, although they contain predominantly anti-parallel beta-sheets [PMID: 11276087, PMID: 8117664, PMID: 12588867].
L-lactate dehydrogenases are metabolic enzymes that catalyse the conversion of L-lactate to pyruvate, the last step in anaerobic glycolysis. L-lactate dehydrogenase is also found as a lens crystallin in bird and crocodile eyes. Malate dehydrogenases catalyse the interconversion of malate to oxaloacetate. The enzyme participates in the citric acid cycle.
O-Glycosyl hydrolases EC:3.2.1. are a widespread group of enzymes that hydrolyse the glycosidic bond between two or more carbohydrates, or between a carbohydrate and a non-carbohydrate moiety. A classification system for glycosyl hydrolases, based on sequence similarity, has led to the definition of 85 different families [PMID: 7624375, PMID: 8535779]. This classification is available on the CAZy (CArbohydrate-Active EnZymes) web site. Because the fold of proteins is better conserved than their sequences, some of the families can be grouped in 'clans'. Glycoside hydrolase family 4 GH4 comprises enzymes with several known activities; 6-phospho-beta-glucosidase (EC:22.214.171.124); 6-phospho-alpha-glucosidase (EC:126.96.36.199); alpha-galactosidase (EC:188.8.131.52).
No terms assigned in this category.