Homologous Superfamily

Lactate dehydrogenase/glycoside hydrolase, family 4, C-terminal (IPR015955)

Short name: Lactate_DH/Glyco_Ohase_4_C

Overlapping entries


This entry represents a structural motif found at the C-terminal of lactate dehydrogenase (EC: malate dehydrogenases (EC:, as well as at the C-terminal of family 4 glycoside hydrolases (EC:3.2.1). These domains have an unusual fold consisting of segregated alpha-helical and beta-sheet regions, although they contain predominantly anti-parallel beta-sheets [PMID: 11276087, PMID: 8117664, PMID: 12588867].

L-lactate dehydrogenases are metabolic enzymes that catalyse the conversion of L-lactate to pyruvate, the last step in anaerobic glycolysis. L-lactate dehydrogenase is also found as a lens crystallin in bird and crocodile eyes. Malate dehydrogenases catalyse the interconversion of malate to oxaloacetate. The enzyme participates in the citric acid cycle.

O-Glycosyl hydrolases EC:3.2.1. are a widespread group of enzymes that hydrolyse the glycosidic bond between two or more carbohydrates, or between a carbohydrate and a non-carbohydrate moiety. A classification system for glycosyl hydrolases, based on sequence similarity, has led to the definition of 85 different families [PMID: 7624375, PMID: 8535779]. This classification is available on the CAZy (CArbohydrate-Active EnZymes) web site. Because the fold of proteins is better conserved than their sequences, some of the families can be grouped in 'clans'. Glycoside hydrolase family 4 GH4 comprises enzymes with several known activities; 6-phospho-beta-glucosidase (EC:; 6-phospho-alpha-glucosidase (EC:; alpha-galactosidase (EC:

GO terms

Biological Process

GO:0005975 carbohydrate metabolic process
GO:0055114 oxidation-reduction process

Molecular Function

GO:0003824 catalytic activity
GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.