Active Site

L-lactate dehydrogenase, active site (IPR018177)

Short name: L-lactate_DH_AS


NAD-dependent L-lactate dehydrogenases from bacteria and eukaryotes functions as the final step in anaerobic glycolysis. Although lactate dehydrogenases have in some cases been mistaken for malate dehydrogenases due to the similarity of these two substrates and the apparent ease with which evolution can toggle these activities, critical residues have been identified [PMID: 11021970] which can discriminate between the two activities.

This entry represents the active site of L-lactate dehydrogenase, and includes a conserved histidine which is essential to the catalytic mechanism.

GO terms

Biological Process

GO:0055114 oxidation-reduction process

Molecular Function

GO:0004459 L-lactate dehydrogenase activity

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
PROSITE patterns