L-lactate dehydrogenase (IPR011304)

Short name: L-lactate_DH

Overlapping homologous superfamilies

Family relationships


This entry represents the NAD-dependent L-lactate dehydrogenases from bacteria and eukaryotes. This enzyme functions as the final step in anaerobic glycolysis. Although lactate dehydrogenases have in some cases been mistaken for malate dehydrogenases due to the similarity of these two substrates and the apparent ease with which evolution can toggle these activities, critical residues have been identified [PMID: 11021970] which can discriminate between the two activities.

GO terms

Biological Process

GO:0055114 oxidation-reduction process

Molecular Function

GO:0004459 L-lactate dehydrogenase activity

Cellular Component

GO:0005737 cytoplasm

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.