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GLU C180 -> GLN VARIANT QUINOL:FUMARATE REDUCTASE FROM WOLINELLA SUCCINOGENES

Source organism: Wolinella succinogenes
Biochemical function: metal ion binding
Biological process: tricarboxylic acid cycle
Cellular component: respirasome

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EC 1.3.5.1: Succinate dehydrogenase (quinone)

Reaction catalysed:
Succinate + a quinone = fumarate + a quinol
Systematic name:
Succinate:quinone oxidoreductase
Alternative Name(s):
  • Complex II
  • SDH
  • Succinate dehydrogenase (ubiquinone)
  • Succinate dehydrogenase complex
  • Succinate:ubiquinone oxidoreductase
  • Succinic dehydrogenase

GO terms

Sequence families

Pfam Protein families (Pfam)
PF01127
Domain description: Succinate dehydrogenase/Fumarate reductase transmembrane subunit
Occurring in:
  1. Fumarate reductase cytochrome b subunit
The deposited structure of PDB entry 2bs3 contains 2 copies of Pfam domain PF01127 (Succinate dehydrogenase/Fumarate reductase transmembrane subunit) in Fumarate reductase cytochrome b subunit. Showing 1 copy in chain C.

PF13183
Domain description: 4Fe-4S dicluster domain
Occurring in:
  1. Fumarate reductase iron-sulfur subunit
The deposited structure of PDB entry 2bs3 contains 2 copies of Pfam domain PF13183 (4Fe-4S dicluster domain) in Fumarate reductase iron-sulfur subunit. Showing 1 copy in chain B.

PF13085
Domain description: 2Fe-2S iron-sulfur cluster binding domain
Occurring in:
  1. Fumarate reductase iron-sulfur subunit
The deposited structure of PDB entry 2bs3 contains 2 copies of Pfam domain PF13085 (2Fe-2S iron-sulfur cluster binding domain) in Fumarate reductase iron-sulfur subunit. Showing 1 copy in chain B.

PF02910
Domain description: Fumarate reductase flavoprotein C-term
Occurring in:
  1. Fumarate reductase flavoprotein subunit
The deposited structure of PDB entry 2bs3 contains 2 copies of Pfam domain PF02910 (Fumarate reductase flavoprotein C-term) in Fumarate reductase flavoprotein subunit. Showing 1 copy in chain A.

PF00890
Domain description: FAD binding domain
Occurring in:
  1. Fumarate reductase flavoprotein subunit
The deposited structure of PDB entry 2bs3 contains 2 copies of Pfam domain PF00890 (FAD binding domain) in Fumarate reductase flavoprotein subunit. Showing 1 copy in chain A.

InterPro InterPro annotations
IPR034804
Domain description: Fumarate reductase/succinate dehydrogenase, transmembrane subunit
Occurring in:
  1. Fumarate reductase cytochrome b subunit
IPR004224
Domain description: Fumarate reductase type B, transmembrane subunit
Occurring in:
  1. Fumarate reductase cytochrome b subunit
IPR017896
Domain description: 4Fe-4S ferredoxin-type, iron-sulphur binding domain
Occurring in:
  1. Fumarate reductase iron-sulfur subunit
IPR027477
Domain description: Succinate dehydrogenase/fumarate reductase flavoprotein, catalytic domain superfamily
Occurring in:
  1. Fumarate reductase flavoprotein subunit
IPR036188
Domain description: FAD/NAD(P)-binding domain superfamily
Occurring in:
  1. Fumarate reductase flavoprotein subunit
IPR000701
Domain description: Succinate dehydrogenase/fumarate reductase type B, transmembrane subunit
Occurring in:
  1. Fumarate reductase cytochrome b subunit
IPR017900
Domain description: 4Fe-4S ferredoxin, iron-sulphur binding, conserved site
Occurring in:
  1. Fumarate reductase iron-sulfur subunit
IPR009051
Domain description: Alpha-helical ferredoxin
Occurring in:
  1. Fumarate reductase iron-sulfur subunit
IPR006058
Domain description: 2Fe-2S ferredoxin, iron-sulphur binding site
Occurring in:
  1. Fumarate reductase iron-sulfur subunit
IPR004489
Domain description: Succinate dehydrogenase/fumarate reductase iron-sulphur protein
Occurring in:
  1. Fumarate reductase iron-sulfur subunit
IPR025192
Domain description: Succinate dehydogenase/fumarate reductase N-terminal
Occurring in:
  1. Fumarate reductase iron-sulfur subunit
IPR001041
Domain description: 2Fe-2S ferredoxin-type iron-sulfur binding domain
Occurring in:
  1. Fumarate reductase iron-sulfur subunit
IPR036010
Domain description: 2Fe-2S ferredoxin-like superfamily
Occurring in:
  1. Fumarate reductase iron-sulfur subunit
IPR012675
Domain description: Beta-grasp domain superfamily
Occurring in:
  1. Fumarate reductase iron-sulfur subunit
IPR015939
Domain description: Fumarate reductase/succinate dehydrogenase flavoprotein-like, C-terminal
Occurring in:
  1. Fumarate reductase flavoprotein subunit
IPR037099
Domain description: Fumarate reductase/succinate dehydrogenase flavoprotein-like, C-terminal domain superfamily
Occurring in:
  1. Fumarate reductase flavoprotein subunit
IPR003952
Domain description: Fumarate reductase/succinate dehydrogenase, FAD-binding site
Occurring in:
  1. Fumarate reductase flavoprotein subunit
IPR014006
Domain description: Succinate dehydrogenase/fumarate reductase, flavoprotein subunit
Occurring in:
  1. Fumarate reductase flavoprotein subunit
IPR003953
Domain description: FAD-dependent oxidoreductase 2, FAD binding domain
Occurring in:
  1. Fumarate reductase flavoprotein subunit
IPR030664
Domain description: FAD-dependent oxidoreductase SdhA/FrdA/AprA
Occurring in:
  1. Fumarate reductase flavoprotein subunit

Structure domains

CATH CATH domains
1.10.1060.10
Class: Mainly Alpha
Architecture: Orthogonal Bundle
Topology: Fumarate Reductase Iron-sulfur Protein; Chain B, domain 2
Homology: Alpha-helical ferredoxin
Occurring in:
  1. Fumarate reductase iron-sulfur subunit
The deposited structure of PDB entry 2bs3 contains 2 copies of CATH domain 1.10.1060.10 (Fumarate Reductase Iron-sulfur Protein; Chain B, domain 2) in Fumarate reductase iron-sulfur subunit. Showing 1 copy in chain B.
3.50.50.60
Class: Alpha Beta
Architecture: 3-Layer(bba) Sandwich
Topology: FAD/NAD(P)-binding domain
Homology: FAD/NAD(P)-binding domain
Occurring in:
  1. Fumarate reductase flavoprotein subunit
The deposited structure of PDB entry 2bs3 contains 2 copies of CATH domain 3.50.50.60 (FAD/NAD(P)-binding domain) in Fumarate reductase flavoprotein subunit. Showing 1 copy in chain A.
1.20.1300.10
Class: Mainly Alpha
Architecture: Up-down Bundle
Topology: 3 helical TM bundles of succinate and fumarate reductases
Homology: Fumarate reductase/succinate dehydrogenase, transmembrane subunit
Occurring in:
  1. Fumarate reductase cytochrome b subunit
The deposited structure of PDB entry 2bs3 contains 2 copies of CATH domain 1.20.1300.10 (3 helical TM bundles of succinate and fumarate reductases) in Fumarate reductase cytochrome b subunit. Showing 1 copy in chain C.
3.10.20.30
Class: Alpha Beta
Architecture: Roll
Topology: Ubiquitin-like (UB roll)
Homology: Ubiquitin-like (UB roll)
Occurring in:
  1. Fumarate reductase iron-sulfur subunit
The deposited structure of PDB entry 2bs3 contains 2 copies of CATH domain 3.10.20.30 (Ubiquitin-like (UB roll)) in Fumarate reductase iron-sulfur subunit. Showing 1 copy in chain B.
3.10.20.820
Class: Alpha Beta
Architecture: Roll
Topology: Ubiquitin-like (UB roll)
Homology: Ubiquitin-like (UB roll)
Occurring in:
  1. Fumarate reductase flavoprotein subunit
The deposited structure of PDB entry 2bs3 contains 2 copies of CATH domain 3.10.20.820 (Ubiquitin-like (UB roll)) in Fumarate reductase flavoprotein subunit. Showing 1 copy in chain A.
1.20.58.100
Class: Mainly Alpha
Architecture: Up-down Bundle
Topology: Methane Monooxygenase Hydroxylase; Chain G, domain 1
Homology: Fumarate reductase/succinate dehydrogenase flavoprotein-like, C-terminal domain
Occurring in:
  1. Fumarate reductase flavoprotein subunit
The deposited structure of PDB entry 2bs3 contains 2 copies of CATH domain 1.20.58.100 (Methane Monooxygenase Hydroxylase; Chain G, domain 1) in Fumarate reductase flavoprotein subunit. Showing 1 copy in chain A.
3.90.700.10
Class: Alpha Beta
Architecture: Alpha-Beta Complex
Topology: Flavocytochrome C3; Chain A, domain 1
Homology: Succinate dehydrogenase/fumarate reductase flavoprotein, catalytic domain
Occurring in:
  1. Fumarate reductase flavoprotein subunit
The deposited structure of PDB entry 2bs3 contains 2 copies of CATH domain 3.90.700.10 (Flavocytochrome C3; Chain A, domain 1) in Fumarate reductase flavoprotein subunit. Showing 1 copy in chain A.
SCOP SCOP annotations
51934
Class: Alpha and beta proteins (a/b)
Fold: FAD/NAD(P)-binding domain
Superfamily: FAD/NAD(P)-binding domain
Occurring in:
  1. Fumarate reductase flavoprotein subunit
The deposited structure of PDB entry 2bs3 contains 2 copies of SCOP domain 51934 (Succinate dehydrogenase/fumarate reductase flavoprotein N-terminal domain) in Fumarate reductase flavoprotein subunit. Showing 1 copy in chain A.
56910
Class: Membrane and cell surface proteins and peptides
Fold: Heme-binding four-helical bundle
Superfamily: Fumarate reductase respiratory complex transmembrane subunits
Occurring in:
  1. Fumarate reductase cytochrome b subunit
The deposited structure of PDB entry 2bs3 contains 2 copies of SCOP domain 56910 (Fumarate reductase respiratory complex cytochrome b subunit, FrdC) in Fumarate reductase cytochrome b subunit. Showing 1 copy in chain C.
46549
Class: All alpha proteins
Fold: Globin-like
Superfamily: alpha-helical ferredoxin
Occurring in:
  1. Fumarate reductase iron-sulfur subunit
The deposited structure of PDB entry 2bs3 contains 2 copies of SCOP domain 46549 (Fumarate reductase/Succinate dehydogenase iron-sulfur protein, C-terminal domain) in Fumarate reductase iron-sulfur subunit. Showing 1 copy in chain B.
54312
Class: Alpha and beta proteins (a+b)
Fold: beta-Grasp (ubiquitin-like)
Superfamily: 2Fe-2S ferredoxin-like
Occurring in:
  1. Fumarate reductase iron-sulfur subunit
The deposited structure of PDB entry 2bs3 contains 2 copies of SCOP domain 54312 (2Fe-2S ferredoxin domains from multidomain proteins) in Fumarate reductase iron-sulfur subunit. Showing 1 copy in chain B.
46978
Class: All alpha proteins
Fold: Spectrin repeat-like
Superfamily: Succinate dehydrogenase/fumarate reductase flavoprotein C-terminal domain
Occurring in:
  1. Fumarate reductase flavoprotein subunit
The deposited structure of PDB entry 2bs3 contains 2 copies of SCOP domain 46978 (Succinate dehydrogenase/fumarate reductase flavoprotein C-terminal domain) in Fumarate reductase flavoprotein subunit. Showing 1 copy in chain A.
56426
Class: Alpha and beta proteins (a+b)
Fold: Succinate dehydrogenase/fumarate reductase flavoprotein, catalytic domain
Superfamily: Succinate dehydrogenase/fumarate reductase flavoprotein, catalytic domain
Occurring in:
  1. Fumarate reductase flavoprotein subunit
The deposited structure of PDB entry 2bs3 contains 2 copies of SCOP domain 56426 (Succinate dehydrogenase/fumarate reductase flavoprotein, catalytic domain) in Fumarate reductase flavoprotein subunit. Showing 1 copy in chain A.

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