Homologous Superfamily

Fumarate reductase/succinate dehydrogenase flavoprotein-like, C-terminal domain superfamily (IPR037099)

Short name: Fum_R/Succ_DH_flav-like_C_sf

Overlapping entries


This entry represents a domain superfamily with a spectrin-repeat-like fold consisting of three helices in a closed bundle with a left-handed twist. This domain superfamily is found in the succinate dehydrogenase/fumarate reductase oxidoreductase family of proteins, such as:

  • L-aspartate oxidase (EC:, a flavoenzyme component of the bacterial quinolinate synthase system that catalyses the conversion of L-aspartate to oxaloacetate, the first step in the de novo biosynthesis of NAD+ [PMID: 11863440, PMID: 10425677].

  • Fumarate reductase, which is part of the quinol-fumarate reductase (QFR) respiratory complex that catalyses the terminal step of anaerobic respiration when fumarate acts as the terminal electron acceptor [PMID: 11850430].

  • Succinate dehydrogenase (SQR; EC:, an iron-sulphur flavoenzyme from bacteria that is analogous to the mitochondrial respiratory complex II, forming part of the electron transport pathway from the electron acceptor (succinate) to the terminal donor (ubiquinone) [PMID: 12560550].

  • Adenylylsulphate reductase A subunit (EC:1.8.4), an iron-sulphur flavoenzyme that catalyses the reversible reduction of adenosine-5'-phosphate (APS) to sulphite and AMP [PMID: 11842205].

GO terms

Biological Process

GO:0055114 oxidation-reduction process

Molecular Function

GO:0016491 oxidoreductase activity

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.